Sharp Look at Complement in Genetics of Macular Degeneration
Last year, four independent research groups reported a linkage between polymorphisms in the complement factor H (CFH) gene to age-related macular degeneration...
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A Tribute to Robert Katzman
Robert Katzman was a pioneer in bringing Alzheimer disease out of obscurity and into the forefront of medical, scientific, and social agenda of this country...
Gammagard™ Misses Endpoints in Phase 3 Trial
Topline data yesterday showed that intravenous immunoglobulin (IVIG) therapy, known as Gammagard™, failed to meet primary endpoints of slowing cognitive and functional decline...
Partners in Crime: APP Fragment and Endosomal Protein Impair Endocytosis
A C-terminal fragment of APP recruits the protein APPL1 to endosomes, causing the enlarged, overactive vesicles seen early in Alzheimer’s disease.
In APP Knock-Ins, Calcium Chaos Dismantles Mushroom Spines
Excess Aβ42 trips up calcium homeostasis and precipitates the loss of spines thought to be important for memory.
Game Over? Federal Trade Commission Calls Brain-Training Claims Inflated
The FTC imposed a $2 million fine on Lumos Labs for overstating the benefits of the company’s Lumosity brain-training software.
Next Up for Human Brain Imaging: Synaptic Density?
Researchers may soon add another imaging agent to their tool kit—one that tracks synapse loss.
Is Tau Phosphorylation All Bad?
At least one phosphate tag may quell Aβ excitotoxicity.
It’s MAGIC: Yeast Mitochondria Make Cytosolic Protein Aggregates Disappear
If it works in neurons, this disposal pathway could have implications for neurodegenerative disease.
What Lies Beneath: Intracranial Probes Pick Up Hippocampal Seizures in AD
Electrodes entering the brain through a hole above the jaw detected epileptic spikes in the hippocampi of Alzheimer’s patients. Scalp recordings missed the action.
Immunotherapy for Cerebral Small Vessel Disease?
An antibody that activates Notch 3 signaling helps keep retinal blood vessels intact in a mouse model of the small vessel disease CADASIL.
Daydreaming Network Serves as Ground Zero for Aβ Deposition
A longitudinal study identified regions in the default mode network as among the first to accumulate Aβ.
There’s No Tomorrow for TOMMORROW
The trial’s sponsor announced an early end to the large Alzheimer’s prevention study based on an interim futility analysis.
In Familial Alzheimer’s, Tau Creeps into Cortex as Symptoms Show
In people with an autosomal-dominant AD mutation, Aβ and tau start accumulating long before the estimated onset of symptoms.
CRISPR Screen Pulls Down Fresh Targets for C9ORF72 ALS
A CRISPR knockout screen in human cells and mouse neurons found genes that tweak C9ORF72 toxicity, zeroing in on ER stress as a potential therapeutic target.
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