Fetal Cell Transplants Do Work in Parkinson's
Ten years after a fetal cell transplant, a Parkinson's patient's graft is still delivering dopamine to postsynaptic cells, according to a study appearing in the December issue of Nature Neuroscience...
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Society for Neuroscience Annual Meeting: Which Aβ Species Is the Culprit?
Dean Hartley (12.5) presented data on the deleterious effects of "protofibrillar" Aβ on neurons. Several other groups have reported that amyloid protofibrils of one sort of another...
Society for Neuroscience Annual Meeting: ApoE Affects Pattern of Amyloid Deposition in Tg Mice
Irizarry and collaborators (626.5) provided intriguing new results from transgenic mouse lines expressing human APP (the PDAPP mice) in the presence or absence of endogenous mouse ApoE...
Presenilin-1 Interferes with Protein Folding
A report in the current Nature Cell Biology describes a mechanism by which presenilin-1 (PS-1) mutations can interfere with protein folding. Kazunori Imaizumi of Osaka University and colleagues suggest that...
Society for Neuroscience Annual Meeting: α-Synuclein: A Review
Hashimoto, Masliah and colleagues (27.14) reported that cytochrome C stimulates α-synuclein aggregration in vitro and that cytochrome C can be observed in Lewy bodies, in postmortem brain tissue...
Society for Neuroscience Annual Meeting: Presenilins: An Overview
Research on presenilins presented at this year's meeting centered around two major questions: 1) What is the role of presenilins in Aβ production and APP processing, and 2) what are the other biological actions of presenilins?...
Society for Neuroscience Annual Meeting: Be Wise—Immunize!
In the relatively short time allotted, Dale Schenk (519.5) managed to describe most of the data from his group’s recent Nature paper (Nature 1999;400:173-177), and a little more...
Society for Neuroscience Annual Meeting: A Sniff of Aβ
Chronic mucosal administration of certain proteins is known to decrease organ-specific autoimmune processes in several autoimmune models, including those affecting the CNS...
Soc for Neuroscience Annual Meeting: Lipoproteins Reduce Clearance of Aβ
Using exquisite human primary cortical cultures containing neurons, astrocytes, and microglia, Nadeau (319.1) demonstrated that addition of VLDLs or HDLs increased media levels of both Aβ40 and Aβ42...
Soc for Neuroscience Ann Mtg: Reduced Cholesterol Levels Inhibit Aβ
Using primary hippocampal neurons transfected with APP by means of the Semliki-forest-virus expression system, Christine Bergmann (319.2) demonstrated that lovastatin (which inhibits de novo cholesterol synthesis)...
Society for Neuroscience Annual Meeting: Intraneuronal Aβ
Until very recently, Aβ accumulation and aggregation were thought to be exclusively extracellular phenomena. However, a number of abstracts presented at this meeting...
Society for Neuroscience Annual Meeting: DIGs—a Site of Aβ?
Kawarabayashi (319.10) presented compelling data for a time-dependent accumulation of Aβ in the detergent-insoluble glycolipid enriched membrane domains (DIGs) of Tg2576 mouse brain...
Society for Neuroscience Annual Meeting: The TGN—Where It's Happening?
In an exhaustive study, Iwata (240.1) presented evidence that the trans Golgi network was the major site of Aβ42 production in both neural and non-neural cells...
Society for Neuroscience Annual Meeting: TACE, TAPI, and ADAM10
The mechanisms of regulated α-secretase cleavage were thoroughly examined in two excellent companion posters from Virginia Lee’s lab...
Society for Neuroscience Annual Meeting: Endocrepsin is BACE
At times the scene around this poster (240.11) was more like a football scrimmage or a rugby scrum than the normally genteel atmosphere associated with a scientific event...
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