Memory Loss—Really Lost or Just Forgotten—New Test Decides
A new type of water maze test can distinguish memory storage from memory retrieval problems in rats...
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Study Poses Cautionary Question: Will Knocking Down Aβ42 Promote Amyloid Angiopathy?
Study shows that parenchymal and vascular amyloidoses are determined by the length of Aβ peptide and suggests that manipulating AβPP cleavage to prevent Aβ42 production could inadvertently cause amyloid angiopathy...
The Wine and Wherefore of Wallerian Degeneration
Lovers of red wine the world over may once again take comfort from the amazing powers of resveratrol, a grape-derived polyphenol that has been shown to extend lifespan in...
ABCA1 Links Cholesterol and ApoE, But It May Not Be a Risk Factor for AD
Independent labs report that the cholesterol transporter ABCA1 keeps brain ApoE levels high and saturated with cholesterol, but a third paper casts doubt on the link between the transporter and AD...
Structure of APP's E2 Domain Revealed: Clues to Physiological Roles?
Try this speculation on for size: Maybe the reason more functional partners for amyloid precursor protein (APP)—whether ligand or receptor—have not yet been found is that...
Prions Proven Infectious?
Prion diseases and Alzheimer’s have some striking parallels, most notably the role played by amyloidogenic peptides. But they have many differences, too...
Tackling Alzheimer’s from the Outside In
Feeling good on the outside often helps us feel good on the inside. Could the same be true for neurons?...
Philadelphia: The Enemy Within—Neurodegeneration From Intraneuronal Aβ
One of the basic research flavors that wafted pungently through the 9th International Conference on Alzheimer’s Disease and Related Disorders is the growing sense that intraneuronal Aβ may...
Philadelphia: Diagnosis Light—Toward Infrared Plaques
If you’ve ever shone a flashlight through your hand and noticed what comes out on the other side, you have seen for yourself why red light could, in theory, make a medium for live diagnostics...
International Conference on Alzheimer's Disease 2004
Philadelphia: All Eyes on PIB Imaging—Is It Coming Along? Philadelphia: All Is Not Well with the Statin Story Philadelphia: Can a Shrinking Brain Be Good for You? Philadelphia: Dementia Types Just Won’t Fit into Little Boxes Philadelphia: Diagnosis Light—
Philadelphia: All Eyes on PIB Imaging—Is It Coming Along?
Brain imaging has emerged as perhaps the most promising source to date of an antecedent marker for Alzheimer's disease...
The Plot Thickens in Huntington's Disease
A study published yesterday in the online Annals of Neurology provides a glimpse at the complexity involved in the time- and cell-specific neurodegeneration of Huntington's disease...
Polymorphisms—Just How Big Are They?
Since the human genome sequence was published, the search for single nucleotide polymorphisms that contribute to disease has ramped up. But what about copy number polymorphisms?...
Philadelphia: Dementia Types Just Won’t Fit into Little Boxes
APP and presenilin mutations cause Alzheimer’s, tau mutations cause tauopathies, and α-synuclein mutations cause Parkinson’s, right? Well, yes, but...
Philadelphia: Can a Shrinking Brain Be Good for You?
Perhaps…yes? At first blush, this is the tentative conclusion one must draw if the results of presentations yesterday on Elan's vaccine...
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