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Snapshots from the Society for Neuroscience Annual Meeting Microglia Control Synapse Number in Multiple Disease States Might Normalizing Brain Development Help in Down’s Syndrome? Potential Parkinson’s Treatments Target α-Synuclein, Cell Replacement Alzhe
Phenotypes vary depending on the partial or full-length nature of the C9ORF72 transgene.
The ALS- and FTD-linked protein condenses into liquid organelles but also tends to form hydrogels, some of which are permanent and toxic.
Basic science inspires conference goers in Chicago.
The ALS-linked RNA may convert free-floating proteins to liquid phase droplets.
C9ORF72 Mice Point to Gain of Toxic Function in ALS, FTD Does C9ORF72 Repeat RNA Promote Protein Phase Transitions? RNA Regulator Locked Out of Nucleus by C9ORF72 Repeats Listen Up, Gene Silencing Strikes a Chord at RNA Meeting Stressed Out: RNA-binding P
Research presented at SfN strengthens the case that microglia gorge on synapses in some neurodegenerative and neurodevelopmental disorders.
The RNA-binding protein hnRNP A3 can help rid a cell of the repeat RNAs, but the RNAs interfere with its nuclear localization.
The protein creeps up in the cerebrospinal fluid as the disease worsens.
Two drugs that boost α-synuclein clearance have passed Phase 1 safety benchmarks, and a stem cell strategy is poised to enter trials, reported scientists at SfN 2015.
Scientists at SfN offer alternate views of Bin1 biology.
John Hardy wins the Breakthrough Prize for his seminal research into the genetic underpinnings of Alzheimer’s disease.
Scientists say treatments to muzzle faulty genes are making some headway.
A philanthropic organization has donated $177 million to train thought leaders from developing nations in dementia care and prevention.
Meet RBM45. This RNA-binding protein and relatively new player in the ALS field associates with stress-induced structures in the cytoplasm and nucleus.
