A new MAO-B inhibitor, rasagiline, proved safe and about as effective as the existing drug, selegiline, in ameliorating symptoms of early Parkinson's. What about its use in Alzheimer's with Parkinsonism?
Dendritic spines—tiny protrusions that mediate synaptic contacts between neurons—are present in vast numbers in the mammalian brain (up to ten thousand per neuron)...
In Alzheimer's, as in many other neurodegenerative diseases, neurons often meet their demise after apoptotic, or programmed cell death pathways have been activated...
Researchers from the biotechnology company SUGEN (a subsidiary of Pharmacia Corporation) and the Salk Institute in La Jolla, California, report that they have mapped all 518 protein kinases in the human genome...
In the December 2 online Journal of Biological Chemistry, researchers extend to mice earlier in-vitro observations linking Aβ degradation to the activity of endothelin converting enzyme (ECE)...
The developmental signaling protein sonic hedgehog (Shh) appears to play a significant role in regulating the proliferation of adult stem cells, according to a report in yesterday’s Nature Neuroscience...
Are you are curious about protein folding and how this fundamental process might go awry in diseases such as Alzheimer’s? If so, you may enjoy reading...
We all know that plants grow toward a light source—but would you believe the same of neurons? Neuronal "phototropism" is exquisitely demonstrated by a report published online in last week's PNAS...
Dinucleotide repeats are scattered throughout the human genome, but do they actually do anything? A report in yesterday's Nature Structural Biology reveals that in some cases at least...
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