Poor Vision Illuminates Zinc-Mediated Protein Misfolding
Protein misfolding and aggregation link Alzheimer's disease with familiar neurodegenerative disorders such as prion disorders or Parkinson's disease, but also some further afield...
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Protein misfolding and aggregation link Alzheimer's disease with familiar neurodegenerative disorders such as prion disorders or Parkinson's disease, but also some further afield...
A troika of papers provides evidence that γ-secretase is primarily localized intracellularly and needs the C-terminus of PEN-2 for complete integration...
Neiman-Pick type C (NPC) disease intrigues Alzheimer's researchers for several reasons. For one thing, the neurodegenerative disorder involves...
A new type of water maze test can distinguish memory storage from memory retrieval problems in rats...
Study shows that parenchymal and vascular amyloidoses are determined by the length of Aβ peptide and suggests that manipulating AβPP cleavage to prevent Aβ42 production could inadvertently cause amyloid angiopathy...
Lovers of red wine the world over may once again take comfort from the amazing powers of resveratrol, a grape-derived polyphenol that has been shown to extend lifespan in...
Independent labs report that the cholesterol transporter ABCA1 keeps brain ApoE levels high and saturated with cholesterol, but a third paper casts doubt on the link between the transporter and AD...
Try this speculation on for size: Maybe the reason more functional partners for amyloid precursor protein (APP)—whether ligand or receptor—have not yet been found is that...
Prion diseases and Alzheimer’s have some striking parallels, most notably the role played by amyloidogenic peptides. But they have many differences, too...
Feeling good on the outside often helps us feel good on the inside. Could the same be true for neurons?...
One of the basic research flavors that wafted pungently through the 9th International Conference on Alzheimer’s Disease and Related Disorders is the growing sense that intraneuronal Aβ may...
If you’ve ever shone a flashlight through your hand and noticed what comes out on the other side, you have seen for yourself why red light could, in theory, make a medium for live diagnostics...
Philadelphia: All Eyes on PIB Imaging—Is It Coming Along? Philadelphia: All Is Not Well with the Statin Story Philadelphia: Can a Shrinking Brain Be Good for You? Philadelphia: Dementia Types Just Won’t Fit into Little Boxes Philadelphia: Diagnosis Light—
Brain imaging has emerged as perhaps the most promising source to date of an antecedent marker for Alzheimer's disease...
A study published yesterday in the online Annals of Neurology provides a glimpse at the complexity involved in the time- and cell-specific neurodegeneration of Huntington's disease...