1998 Society of Neuroscience Meeting: AD Plaques Associated with Curvier Dendrites
Are both Aβ and the intracellular hyperphosphorylation of tau necessary for the induction of morphological alterations in dendrites in AD?...
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1998 Society for Neuroscience Meeting: Frameshift Mutations Precede Tangles, Plaques in DS
Fred van Leeuwen and his research group presented new data regarding their molecular misreading hypothesis for sporadic AD (Abstract 107.7)...
1998 Society for Neuroscience Meeting: Aβ vs. APP Effects in Transgenics
Hopefully, transgenic AD models will be more useful than just demonstrating that the overexpression of mutant human APP can lead to the deposition of Aβ plaques...
1998 Society for Neuroscience Meeting: α2-Macroglobulin
AD is now widely considered to be a multifactorial disease with only a few dominant genetic mutations that can be considered as directly causing the disease, i.e., APP and the presenilins...
New Path for Aspirin
It is known that aspirin and sodium salicylate suppress inflammation by inhibiting cyclooxygenase, an enzyme that triggers production of prostaglandin. It has been suspected that these compounds...
Humans Sprout New Neurons
It has long been a dogma of neuroscience that the human brain is born with all the neurons it will ever have, and that those neurons must endure for a lifetime. But evidence has been accumulating...
Stem Cells Take a Leap Forward
The idea of treating developmental and neurodegenerative disorders by growing new brain cells has taken a major step forward, according to results of two studies...
Neuronal Loss in Mouse Model?
Can transgenic mice serve as a truly useful model for studying Alzheimer's disease? Studies of mice expressing an APP gene mutation that causes a form of familial AD have reported no neuronal loss...
Mutant PS1 Destabilizes β-Catenin
Since the discovery that mutations in the gene for PS1 cause familial Alzheimer disease, there has been keen interest in investigating the mechanism by which PS1 mutations cause disease...
Soccer Bad for Brain
A study published in last month's Neurology reports that professional soccer players are at significantly higher risk for long-term brain injuries that affect their mental function...
Eat That Spinach!
A diet rich in certain fruits and vegetables is known to protect against cancer and heart disease, and now a new animal study suggests nutrition can also stall the decline of brain function...
Estrogen Reduces Parkinson's Risk
Estrogen has been shown in recent years to be a possible protective factor in Alzheimer disease, and now new studies suggest it may also protect against the risk of Parkinson's disease...
APP Enhances Mouse Memory
Secreted forms of amyloid precursor protein (APP) may play an important role in the formation and consolidation of memory, according to a study published in today's proceedings of the National Academy of Science...
Neurological Disease Institute Launched at UCSF
A research center focusing on advancing scientific understanding of brain disorders such as Alzheimer's disease, HIV dementia and stroke, was inaugurated earlier this month at UCSF...
Nature Online
The British science journal Nature announced that it is becoming a "full-fledged" electronic journal beginning with this week's issue (at <a href="http://www.nature.com">http://www.nature.com</a>)...
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