New Marker for AD on the Horizon?
The chemokine receptor CCR1 might be an early and specific marker of Alzheimer's disease, researchers suggest in the November issue of Annals of Neurology, now available online...
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The chemokine receptor CCR1 might be an early and specific marker of Alzheimer's disease, researchers suggest in the November issue of Annals of Neurology, now available online...
In this week's advanced online edition of PNAS, researchers report that presenilin (PS), the aspartyl protease proposed to be the heart of γ-secretase, may function as a dimer...
Interview with Akihiko Takashima, RIKEN Brain Science Institute, Wako, Saitama, Japan
Immune molecules, thought to act exclusively in the periphery presenting antigens and fighting infection, in fact, have an alter ego in the brain's neurons, where they help remodel synapses in response to neural activity. How's this for a wild idea in AD research: Could it be that synapses are attacked in a misguided immune response...
A classic case of scientific serendipity has added an ironic wrinkle to the prion story. An article in today's Nature shows intriguing evidence that prions may indeed need nucleic acids to infect hosts-yet these nucleic acids may come from the host itself...
Shedding light on why mutations in parkin protein might cause familial Parkinson's disease, a study in the October 6 online PNAS shows how overexpression of one of parkin's targets can cause degeneration of dopamine neurons in vivo...
If humans are almost genetically identical to their primate relatives, what is it that makes us smarter? In this week’s PNAS early online edition, researchers suggest that the greater brain power is due to elevated gene expression...
In Alzheimer’s patients, a portion of soluble amyloid-β peptides (sAβ) never makes it out of the brain as in normal subjects, ending up instead in amyloid fibrils or plaques. A trio of recent papers explores factors that determine the fate of these peptides...
One well-characterized cause of amyotrophic lateral sclerosis (ALS) is mutation of the copper-zinc isoform of superoxide dismutase (SOD), causing progressive degeneration of motor neurons. But must these mutations occur in neurons to be detrimental? A report in today’s Science suggests...
Using time-lapse imaging to follow the path of mutant huntingtin protein from expression through cell death, researchers believe they have laid to rest a much-debated theory of pathogenesis of Huntington's disease...
Two papers in the 25 September Neuron move axonal transport squarely into the limelight of research on triplet-repeat (or polyQ) diseases, including Huntington’s...
Gleevec, the cancer "wonder drug" that has proven effective for gastrointestinal stromal tumors might also be useful for Alzheimer's patients, if only one could deliver it to the brain effectively...
The September 21 online Nature Neuroscience reports that the serine-threonine kinase Cdk5, which is known to phosphorylate the neurofibrillary tangle protein tau, is essential for ischemia-provoked death of hippocampal CA1 neurons...
Brian Bacskai and colleagues from Massachusetts General Hospital, Charlestown, and Bill Klunk and colleagues at the University of Pittsburgh, Pennsylvania, show that they can image the uptake, labeling of amyloid plaques, and subsequent release of the thioflavin derivative Pittsburgh compound B (PIB)...
A new study adds support to the theory that a critical first step in the production of the Aβ peptide by the BACE enzyme occurs primarily in specialized, cholesterol-rich areas of the plasma membrane called "lipid rafts"...