Memantine Relieves Symptoms in Moderate to Severe AD
The drug memantine can benefit patients with moderate to severe Alzheimer's disease, according to a study reported in the April 3 New England Journal of Medicine...
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Prospects for Growth Hormone Therapy Shrink in Alzheimer’s Trial
The hormone dehydroepiandrosterone (DHEA) failed to significantly improve cognition in a small pilot trial of patients with Alzheimer's disease, according to a report in the April issue of Neurology...
Bill Klunk Reports from Paris on The Living Brain and Alzheimer’s Disease
After well-deserved "thank you’s" to Yves Christen and Jacqueline Mervaillie of the IPSEN Foundation, who organized this conference held on 17 March 2003, Brad Hyman’s introductory remarks reviewed...
Ceramide Leads to Higher BACE Levels
A paper in press in the Journal of Biological Chemistry reports that the lipid ceramide may contribute to the formation of amyloid deposits found in Alzheimer's disease patients because it stabilizes BACE...
Stem Cell Fusion Is for Real
Transplanted blood progenitor cells can help repopulate a diseased liver, but they do this by fusing with existing liver cells, as opposed to reverting to a more pluripotent stem cell identity...
Parkinson's Researchers Pumped by Trial; L-DOPA Makes Synapses Hyperactive
In today's Nature journals online, two articles provide new insights and new hope for the treatment of Parkinson's disease...
Ironing out the Role of Metals in Neurodegenerative Diseases
A large, collaborative group led by Julie Andersen at the Buck Institute for Research in Aging, Novato, California, demonstrates that lowering the bioavailability of iron—both systemically and in dopaminergic neurons—protects mice against chemically induced Parkinson's...
Deficit in Insulin-Degrading Enzyme Yields Increased Aβ and Intracellular Domain
Extending in-vitro evidence that insulin-degrading enzyme (IDE) may be involved in the clearance of the Aβ peptide, a report in the 12 March issue of PNAS finds that IDE knockout mice have higher cerebral accumulation of both Aβ and the AβP intracellular domain...
Neuregulin and Notch Signalling Linked in Developing Brain
The family of neuregulin-1 growth and differentiation factors is rapidly piquing the interest of researchers in areas ranging from schizophrenia to Alzheimer's disease...
Does Aβ Normally Rein in Excited Synapses?
The normal role of Aβ is intimately tied up with synaptic electrophysiology. On the flip side, disturbances in the regulatory interplay between synaptic activity and AβP processing could yield clues to a better explanation of how...
Trials and Tribulations—Autopsy Reveals Pros and Cons of AD Vaccine
In an advanced online publication in this week's Nature Medicine, doctors report the first autopsy of a patient enrolled in trials for the ill-fated Alzheimer's disease (AD) vaccine...
Neuron Recognition Gone to Potts
Researchers have used the well-established Potts model—an algorithm mathematicians and biologists use to measure how individual entities behave in relation to their neighbors—to help map the spatial organization of neurons...
Ipsen Colloquium on Alzheimer’s Disease 2003
Bill Klunk Reports from Paris on The Living Brain and Alzheimer’s Disease Ipsen Colloquium on Alzheimer’s Disease 2003
Astrocytes—Part of the Solution or Part of the Problem?
While recent evidence suggests that astrocytes may help degrade β amyloid, a report in the March 7 online Journal of Biological Chemistry suggests they may also help produce it...
Breaking Away: Human Glial Stem Cells Generate Neurons
The stem cells populating the white matter tracts in human brain can generate neurons, apparently just by being removed from an environment that limits them to a glial fate...
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