TREM2 Binds Aβ, Reprograms Microglia to Curb Plaques
Two new papers strengthen the evidence that TREM2 protects against amyloid pathology.
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AbbVie’s Tau Antibody Flops in Progressive Supranuclear Palsy
The company halted its Phase 2 trial of ABBV-8E12 due to lack of efficacy.
In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation
Two papers report that the ApoE4 allele triggers both hallmarks of AD in iPSC-derived cultures, in contrast to its minimal effects in mouse neurons.
Imaging Model Locates Epicenter of Disease, Predicts Atrophy
By analyzing a single MRI scan, researchers pinpointed the origin of frontotemporal dementia pathology and predicted its future progression.
Acetaminophen Derivative Tempers Microglia, Spurs Plaque Clearance
DAPPD suppressed neuroinflammation and preserved cognition in mouse models of amyloidosis, suggesting potential for treating Alzheimer’s disease.
Microglia Inflammasome Stokes Tau Phosphorylation, Tangles
In a mouse tauopathy model, knocking out the NLRP3 inflammasome prevented toxic tau from forming.
Human and Mouse Microglia React Differently to Amyloid
Single-nucleus transcriptomics of postmortem AD brain and mouse models of amyloidosis hammers home the species-specific responses of microglia to Aβ pathology.
Exposure, Exposure, Exposure? At CTAD, Aducanumab Scientists Make a Case
Biogen researchers claim the antibody worked in people who got enough of it. To other researchers, the signal validates the amyloid hypothesis and injects fresh energy into the field. But is this interrupted dataset enough to approve?
Protective APP Mutation Found—Supports Amyloid Hypothesis
Does β amyloid accumulation drive Alzheimer’s disease?...
New Parkinson’s Gene: DJ Mutations Make Neurons Change Their Tune
In today's SciencExpress, researchers from Italy, France, and The Netherlands report that mutations in DJ-1, a protein of unknown function, can lead to Parkinson's disease...
Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition
Hippocampal imaging and fluid markers of BBB damage found in ApoE4 carriers.
An Antimicrobial Approach to Treating Alzheimer’s?
A periodontal pathogen found in human brains triggers AD pathology in mice. Will an antibiotic stave off dementia?
Social Distancing Shutters Alzheimer’s Research
With experiments and careers on hold, scientists working from home are turning to virtual lab meetings and journal clubs to keep up morale.
Human Blood-Brain Barrier Model Blames Pericytes for CAA
When these tiny mural cells carried APOE4, they secreted more ApoE, causing Aβ to deposit in capillary walls. Blocking ApoE production prevented angiopathy.
Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
Live imaging of mouse brain reveals that microglia quickly engulf cell bodies while astrocytes dispose of the neuron’s more distal reaches. The cleanup crew tires with age.
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