Two new papers strengthen the evidence that TREM2 protects against amyloid pathology.
The company halted its Phase 2 trial of ABBV-8E12 due to lack of efficacy.
Two papers report that the ApoE4 allele triggers both hallmarks of AD in iPSC-derived cultures, in contrast to its minimal effects in mouse neurons.
By analyzing a single MRI scan, researchers pinpointed the origin of frontotemporal dementia pathology and predicted its future progression.
DAPPD suppressed neuroinflammation and preserved cognition in mouse models of amyloidosis, suggesting potential for treating Alzheimer’s disease.
In a mouse tauopathy model, knocking out the NLRP3 inflammasome prevented toxic tau from forming.
Single-nucleus transcriptomics of postmortem AD brain and mouse models of amyloidosis hammers home the species-specific responses of microglia to Aβ pathology.
Biogen researchers claim the antibody worked in people who got enough of it. To other researchers, the signal validates the amyloid hypothesis and injects fresh energy into the field. But is this interrupted dataset enough to approve?
Does β amyloid accumulation drive Alzheimer’s disease?...
In today's SciencExpress, researchers from Italy, France, and The Netherlands report that mutations in DJ-1, a protein of unknown function, can lead to Parkinson's disease...
Hippocampal imaging and fluid markers of BBB damage found in ApoE4 carriers.
A periodontal pathogen found in human brains triggers AD pathology in mice. Will an antibiotic stave off dementia?
With experiments and careers on hold, scientists working from home are turning to virtual lab meetings and journal clubs to keep up morale.
When these tiny mural cells carried APOE4, they secreted more ApoE, causing Aβ to deposit in capillary walls. Blocking ApoE production prevented angiopathy.
Live imaging of mouse brain reveals that microglia quickly engulf cell bodies while astrocytes dispose of the neuron’s more distal reaches. The cleanup crew tires with age.