In yesterday’s Sciencexpress, researchers described the most complete annotation of human chromosome 7 to date. Capitalizing on the availability of clinical and medical information from a variety of databases...
The drug memantine can benefit patients with moderate to severe Alzheimer's disease, according to a study reported in the April 3 New England Journal of Medicine...
The hormone dehydroepiandrosterone (DHEA) failed to significantly improve cognition in a small pilot trial of patients with Alzheimer's disease, according to a report in the April issue of Neurology...
After well-deserved "thank you’s" to Yves Christen and Jacqueline Mervaillie of the IPSEN Foundation, who organized this conference held on 17 March 2003, Brad Hyman’s introductory remarks reviewed...
A paper in press in the Journal of Biological Chemistry reports that the lipid ceramide may contribute to the formation of amyloid deposits found in Alzheimer's disease patients because it stabilizes BACE...
Transplanted blood progenitor cells can help repopulate a diseased liver, but they do this by fusing with existing liver cells, as opposed to reverting to a more pluripotent stem cell identity...
A large, collaborative group led by Julie Andersen at the Buck Institute for Research in Aging, Novato, California, demonstrates that lowering the bioavailability of iron—both systemically and in dopaminergic neurons—protects mice against chemically induced Parkinson's...
Extending in-vitro evidence that insulin-degrading enzyme (IDE) may be involved in the clearance of the Aβ peptide, a report in the 12 March issue of PNAS finds that IDE knockout mice have higher cerebral accumulation of both Aβ and the AβP intracellular domain...
The family of neuregulin-1 growth and differentiation factors is rapidly piquing the interest of researchers in areas ranging from schizophrenia to Alzheimer's disease...
The normal role of Aβ is intimately tied up with synaptic electrophysiology. On the flip side, disturbances in the regulatory interplay between synaptic activity and AβP processing could yield clues to a better explanation of how...
In an advanced online publication in this week's Nature Medicine, doctors report the first autopsy of a patient enrolled in trials for the ill-fated Alzheimer's disease (AD) vaccine...
Researchers have used the well-established Potts model—an algorithm mathematicians and biologists use to measure how individual entities behave in relation to their neighbors—to help map the spatial organization of neurons...
While recent evidence suggests that astrocytes may help degrade β amyloid, a report in the March 7 online Journal of Biological Chemistry suggests they may also help produce it...