A multi-institutional collaboration has vaccinated rhesus monkeys (<em>Macaca mulatta</em>) against the Aβ peptide in an effort to establish a more human-like animal model than mice for use in vaccination studies...
Researchers who follow the ups and downs of protein expression in Alzheimer’s disease (AD) may well think they are being taken on a roller coaster ride. Early on, many proteins are...
A report in press in the Journal of Biological Chemistry, published online February 24, adds to the growing body of evidence that traces the etiology of Parkinson's disease to the mitochondria...
The Alzheimer Research Forum congratulates three esteemed scientists, and occasional contributors to this website, on the awards they won this past week...
In the current Archives of General Psychiatry, researchers compile an overview of the known genetic components of major brain diseases and then apportion the cost to society accordingly. AD comes out...
In this week’s PNAS, researchers report that brain-derived neurotrophic factor (BDNF) protects newborn neurons in songbirds. BDNF has also been linked to...
The triplet repeat disease X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion in the androgen receptor (AR) gene. Just how this expansion causes degeneration of lower motor neurons...
PAR-1, a homologue of microtubule-affinity regulating kinase (MARK), kicks off the phosphorylation events that culminate in cell death in a fly model of tauopathy, according to...
Where there is more BACE, there is more Aβ. Researchers show that increased BACE expression and activity correlate with increased Aβ production in the frontal cortex of AD patients...
Amyloidoses are a varied and complex set of syndromes caused by aggregation of specific proteins such as the amyloid-β, found in the brains of Alzheimer's patients, and...
As drug discovery in AD research is shifting from inhibiting the γ-secretase to inhibiting the β-secretase (BACE), interest in the entire life cycle of BACE has grown, concomitantly...
The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients...
Amyloid-β precursor protein (AβPP) has gained a notorious reputation because it releases the Aβ peptide that gums up intraneuronal spaces in Alzheimer's brains. Like many of notoriety, however, AβPP probably has a good side...