Uppsala: Immunotherapy and Biomarkers Take Center Stage
In addition to immunotherapy, a meeting in Uppsala, Sweden, focused on recent progress in the development of novel disease biomarkers...
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Québec: Chromogranins Help SOD1 Do Its Dirty Work
Mutant superoxide dismutase 1 (SOD1) has been linked to one-fifth of inherited cases of ALS, where its misfolded form appears to damage motor neurons...
Meet Norbin—Behind the Scenes Player at mGluR5
The mGluR5 modulator Norbin presents a possible new drug target for schizophrenia...
Model Shows Oligomers Impair Memory, Questions Role of Prion Protein
When it comes to the synaptic toxicity and cognitive dysfunction in AD, a preponderance of evidence points to soluble oligomers of Aβ peptides as the main villains...
Toxic Elk-1 Phosphoform Found in AD, HD, Lewy Body Disease Inclusions
The protein aggregates that brew discord in several neurodegenerative diseases may have some troublemakers in common...
Shall We Dance? Isomerases Twist With Tau, Synuclein, Ca2+ Channels
Proline is a unique amino acid and is the only one of the standard 20 that is cyclic and exists in cis and trans isoforms...
CaMKII: More Than Just an Enzyme; It’s a Scaffold, Too
To form and cement memories, the synapse must restructure itself, breaking down some proteins and rebuilding new configurations...
Convergence Zone: NRG1 Signaling Linked to DISC1, BACE1
A new study reveals an intriguing link between two top suspects in schizophrenia, neuregulin-1 (NRG1) and disrupted in schizophrenia-1 (DISC1)...
Synapses: Aβ and Tau Reside There, Cdk5 Shows Up Again
Two papers out this week focus on synapses, their contents and function, and how amyloid-β (Aβ) might play into both...
ApoE4 and Aβ: Partners in Crime?
Though ApoE4 is the most prevalent genetic risk factor for Alzheimer disease, its role in pathology has been tricky to pin down...
What’s Up With AD-Linked APP Fragments, Networks in Young People’s Brains?
Fragments of amyloid-β precursor protein (APP) previously associated with Alzheimer disease pathology are present at dramatically higher levels in the brains of young, perfectly normal adults...
ALS Research: More TDP-43, and Peripherin No Longer in Periphery?
In ALS and other neurodegenerative disorders, a newer player could be joining the current star under the limelight...
Does APP Signaling, Even Diabetes, Depress Neurogenesis?
The relatively recent realization that neurogenesis is alive and kicking in the adult hippocampus has scientists wondering if the phenomenon can be exploited...
Required Reading—InteracTomes for AD, Aging, APP
Fundamental knowledge gaps in Alzheimer disease research include a clear grasp of the normal role of the amyloid precursor protein (APP), and the molecular basis for the increased risk for AD as people age...
San Diego: Exploring the Role of APP in Transit
At this year’s Society for Neuroscience annual meeting, a special ancillary symposium explored the normal and pathological roles of APP...
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