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At CTAD, former FDA neurology leader Rusty Katz urged Alzheimer’s trialists to stop fussing over disease progression. He recommended going after a large effect, regardless of whether it can garner a label of disease modification. That, he says, may mean combination trials.
Gastrointestinal adverse events prompted the FDA to press the pause button on the α7 nicotinic acetylcholine receptor agonist.
Two new papers add to growing evidence linking diabetes and neurodegenerative disease...
At the 8th annual Eibsee Meeting on Cellular Mechanisms of Alzheimer’s Disease, two speakers presented advances in the development of immunotherapies for AD...
At a meeting in San Diego, researchers traded news about how TDP-43 gets trapped in the cytoplasm, finding both good and bad consequences of its exodus from the nucleus.
At an RNA metabolism meeting, scientists reported connections between C9ORF72 loss and gain of function. Their talks brimmed with new biology implicating autophagy, the cellular stress response, and RAN translation off introns.
Staufen1 may deplete certain mRNAs, precipitating the death of Purkinje and other neurons.
Though the dipeptides interacted with many proteins in cell culture, they associated specifically with ribosomes in the human brain.
The brain’s resident immune cells secrete galectin-3, which activates other nearby microglia to promote neuroinflammation.
Researchers at BACE meeting explore how trafficking and degradation of the protease relate to amyloid pathology in AD.
As new substrates and functions for BACE continue to emerge, scientists worry about adverse effects of blocking the protease.
Researchers find an actin-binding protein in stress granules, linking the cytoskeleton and RNA sequestration in the pathology of amyotrophic lateral sclerosis.
The light, medium, and heavy chains of neurofilament assemble together to form axonal girders, but researchers report that peripherin joins in as a fourth member of the filaments...
Polymorphisms in the gene for leucine-rich repeat kinase 2 (LRRK2) confer risk for both familial and sporadic forms of Parkinson’s disease...
At the 23rd annual International Symposium on ALS/MND, genetics was, as ever, a hot topic...
