Aβ Oligomers—Small Steps in Detection, Characterization
Since they were discovered to be a major toxic species, Aβ oligomers have haunted many a research lab...
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Tau Vaccine Detangles Mouse Brain
Vaccination is not just for amyloid anymore...
Stress Granules: No Incubator for Inclusions, After All?
Using a new optogenetic model for TDP-43 phase transitions, scientists see the protein aggregate outside, not inside stress granules. The model distinguishes physiological from abnormal phase transition.
A NAC1 for Recruiting the UPS to Dendritic Spines
Dysfunction of the ubiquitin-proteasome system (UPS)...
Glaucoma, AD of the Eye?
Glaucoma and Alzheimer disease (AD) might share more than being chronic, age-related diseases with devastating neurodegeneration...
Parkinson Disease—Potential Targets, Therapies
The basic understanding of Parkinson disease, the second most common neurodegenerative disorder after Alzheimer’s, is...
Parkinson Update: New Data Reveals Complexities of PINK1, DJ-1 Biology
Since mutations in the PINK1 and DJ-1 genes were found to cause autosomal recessive forms of Parkinson disease...
ApoE—Breaking Ties to Aβ Offers Potential Therapy
The human ApoE4 isoform is the biggest single risk factor for sporadic Alzheimer disease (AD)...
Paper Alert: Nipping Tau Tangles in the Bud
Just as amyloid-β toxicity may be attenuated by proteases such as insulin degrading enzyme and neprilysin, tau toxicity...
What Role BDNF?—A Question of Maturity
In life, you wouldn’t trust a child to do an adult’s job. In the brain, the same might be true...
SfN: Where, How Does Intraneuronal Aβ Pack Its Punch? Part 1
The story of intraneuronal Aβ has generated a steady buzz at the 35th Annual Meeting of the Society for Neuroscience...
SfN: Where, How Does Intraneuronal Aβ Pack Its Punch? Part 3
This is the third installment of a four-part news series about intraneuronal Aβ from the 35th Annual Conference of the Society for Neuroscience...
SfN: Latest Intel on LRRK2, Parkin
In the aftermath of a recent spate of gene discoveries for Parkinson disease, some of the prizes scientists were chasing...
Secretion of SOD1 Mutant Proteins Tied to ALS
In amyotrophic lateral sclerosis (ALS), motor neurons in the spinal cord and central nervous system die off for unknown reasons...
Translational Biomarkers in Alzheimer Disease Research, Part 3
This is part 3 of a 5-part series. See also <a href="/news/conference-coverage/translational-biomarkers-alzheimer-disease-research-part-1">part 1</a> and <a href="/news/conference-coverage/translational-biomarkers-alzheimer-disease-research-part-2">part 2</a>...
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