Is Motor Neuron Troublemaker Just a Bad Driver?
The protein survival of motor neuron (SMN), whose absence causes spinal muscular atrophy, has a new charge: an mRNA needed to make neuromuscular junctions...
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Uppsala: Is Tau Immunotherapy Taking Off?
Targeting extracellular Aβ with immunotherapy is one thing, but could antibodies even drive the clearance of tau, a predominantly intracellular protein?...
Uppsala: Immunotherapy—Not Just for AD Anymore
As immune-based therapies targeting Aβ and tau are beginning to show promise for the treatment of Alzheimer’s, what about other disorders of the nervous system?...
ALS: Mutant Enzyme Does Not Hang Around, But Does Find Mitochondria
Although it seems that many deficiencies can lead to ALS, the enzyme SOD1 has long received the lion’s share of attention...
Hedgehog Protocol Turns Supersonic in Faster Route to Motor Neurons
For researchers keen to understand ALS and other motor neuron conditions, making just a few motor neurons over months hampers their studies...
ALS—A Polyglutamine Disease? Mid-length Repeats Boost Risk
Researchers have mediated a merger of sorts between two distinct neurodegenerative conditions—ALS and (SCA)—and the proteins that cause them...
St. Louis: ApoE—A Clearer View of its Role In AD?
ApoE receptors enable a flurry of activity, much of it totally independent of amyloid-β pathology...
Mutant SOD1 Inflames If Not Quenched by Autophagy
Misfolded proteins can gum up the cell’s works by glomming together and boosting inflammation...
Aβ STATs—Transcription Factor Implicated in Toxicity
Though it has been decades since amyloid-β was implicated in the pathology of AD, it is still not exactly clear how the peptide is toxic...
Triple Trouble: AD Mice Decline Faster With Lewy Bodies
The blend of AD and PD features in dementia with Lewy bodies (DLB) make it one of the most challenging neurodegenerative disorders to study...
Where’s the FUS?—Evidence for Sporadic ALS Role Creates Stir
Although most cases of amyotrophic lateral sclerosis have no evidence of inheritance, scientists are finding valuable clues to the disease among familial cases...
Optineurin Mutations Cause ALS, If Not Glaucoma
As if blindness wasn’t enough, mutations in the gene for optineurin (OPTN), which can lead to glaucoma, also appear to cause amyotrophic lateral sclerosis...
Geneva: Biomarker News Morsels Amid Immunotherapy Review
Advances in therapy saw little sprigs of news pop up in talks that otherwise took stock of the current status of immunotherapy as one of the major new approaches...
Norepinephrine Fuels Microglial Migration, Aβ Phagocytosis
A report offers a mechanism for how loss of locus ceruleus neurons could contribute to AD pathogenesis...
Uppsala: Immunotherapy and Biomarkers Take Center Stage
In addition to immunotherapy, a meeting in Uppsala, Sweden, focused on recent progress in the development of novel disease biomarkers...
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