Meeting Explores Complex Biology of BACE Regulation
Researchers at BACE meeting explore how trafficking and degradation of the protease relate to amyloid pathology in AD.
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BACE—Substrates, Functions, Developmental Phenotypes
As new substrates and functions for BACE continue to emerge, scientists worry about adverse effects of blocking the protease.
Profilin-1 Links Cytoskeleton and RNA Aggregation in ALS
Researchers find an actin-binding protein in stress granules, linking the cytoskeleton and RNA sequestration in the pathology of amyotrophic lateral sclerosis.
One, Two, Three…Four? Peripherin Jams With Neurofilament in Quartet
The light, medium, and heavy chains of neurofilament assemble together to form axonal girders, but researchers report that peripherin joins in as a fourth member of the filaments...
The Many Faces of LRRK2
Polymorphisms in the gene for leucine-rich repeat kinase 2 (LRRK2) confer risk for both familial and sporadic forms of Parkinson’s disease...
Chicago—ALS Protein SOD1 Painted as Disease Template
At the 23rd annual International Symposium on ALS/MND, genetics was, as ever, a hot topic...
Zuers—No Pill or Drip: Scientists Inject Phage Drug Into CSF
The meeting featured alternative treatment approaches that are trying to reach the starting line for clinical trials...
Microglia Activation—Venusberg Meeting Questions M1, M2 Designations
Researchers have tried to tie M1 and M2 status to pathology in neurodegenerative diseases, but leaders in neuroinflammation are beginning to question their usefulness...
Tau, α-Synuclein Spread: Crazy Stuff—How Might It Work?
Many researchers believe that neurodegeneration's takeover of one's brain might be driven by pathogenic, misfolded proteins spreading through interconnected neural networks...
Blessing or Curse? Peripheral Cytokines in the Brain
The subject of crosstalk between the peripheral circulation and the central nervous system permeated conversation...
ALS: Many Disparate Diseases, or Just Two?
ALS is a many-headed beast: Several genes can cause it, or no genes at all, and several cell types are involved beyond the motor neurons that actually degenerate...
Going It Alone—APP, BACE1 Take Distinct Routes to Endosome
Researchers show that APP and β-secretase (BACE1) take different paths to meet in early endosomes, the primary site of Aβ generation...
Traffic Control—Curb Endocytosis to Curb AD Pathogenesis?
One study views Aβ production as a normal part of synaptic plasticity, while another starts with the premise that Aβ buildup in neurons is a bad thing...
DC: Where Does TDP-43’s Toxic End Really Come From?
Clearly, the C-terminal of TDP-43 has something to do with amyotrophic lateral sclerosis...
TDP-43 Hangs Out With NF-κB, Puts Innate Immunity Into Hyperdrive
TAR DNA binding protein 43, is in the middle of an abnormal innate immune response that compromises the spinal cord of people with the disease...
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