Human Aβ Vaccine Snagged by CNS Inflammation
Elan Corporation announced last Thursday that it would temporarily suspend further drug administration in the clinical phase 2A trial of its therapeutic vaccine AN-1792...
ALL NEWS
5724 RESULTS
Sort By:
- Most Recent
- Most Commented
The Problem with Interleukin-6
Since it became clear that Alzheimer's disease has features in common with chronic inflammation, much effort has gone into determining whether the various inflammatory response molecules are helping to protect, or to destroy, vulnerable neurons...
Protein-Protein Interactions, Cytoskeleton Implicated in Huntington's
Huntington's disease (HD) is caused by polyglutamine (polyQ) expansion within the huntingtin protein (Htt), but the sequence of events leading to neurodegeneration remains unclear...
Urocortin Is Potent Protector of Hippocampal Neurons
Low concentrations of the hormone urocortin protects cultured hippocampal neurons from a number of toxic agents, including Aβ, according to an article in the current Journal of Neuroscience...
Data-mining Method Unmasks Pathogenic Sequences Lurking in Human DNA
Over the past decade, it has become clear that microorganisms are vastly more diverse and ubiquitous than our egocentric species ever thought possible. This has led some scientists to suspect that microbes may be causing human diseases...
Good Copper, Bad Copper: News on this Metal's Role in Alzheimer's
Though considerable effort has been spent over the last few decades investigating the relationship between Alzheimer's disease and aluminum, the role of the transition metal remains controversial...
Functional MRI Images Drug-Induced Memory Impairment
The case for using magnetic resonance imaging to monitor changes associated with memory loss or cognitive impairment was boosted by research published in last week's PNAS...
New PET Probe to Aid Diagnosis and Monitoring of Alzheimer's Disease
Scientists have been racing to develop simple, non-invasive, and accurate tools for the early diagnosis of Alzheimer's disease (AD). Recently, brain imaging has received a boost by the findings of Silverman et al...
Transgenics Made Easy? Lentivirus Found to Carry Genes into Mice, Rats
Transgenic mice have become a staple in the study of basic biology and disease, including Alzheimer's. Even so, the method predominantly used today to create these animals remains technically difficult, costly, and impractical in other animal species...
News on the Molecular Biology of Aging
P53 misregulation and cancer have become almost synonymous in the scientist's imagination. Mutations in this prominent tumor suppressor gene have been found in the majority of human cancers...
Active Life of Leisure Appears to Build Reserves Against AD
A study in last month's Neurology provides more evidence that people who engage in little leisure activity are at greater risk for developing Alzheimer's disease. The study, by Yaakov Stern et al. at Columbia University, New York, is noteworthy...
Transgenic Mice Accumulate Human Tau in Degenerating Hippocampal Neurons
The question of how neurofibrillary tangles (NFTs) contribute to the profound loss of neurons in Alzheimer's disease remains unsettled in part because of a dearth of suitable animal models...
Molecular Chaperones Can Ameliorate Neuronal Loss in Drosophila PD Model
In 1999, Warrick et al. showed that the molecular chaperone Hsp70 could suppress neurodegeneration mediated by polyQ expansions in a protein associated with spinocerebellar ataxia...
Is It to Be Red or White with Your Christmas Turkey?
Just in time to ponder this weighty question comes a short communication in tomorrow's Nature. Martin Carrier and colleagues at the William Harvey Research Institute in London report that polyphenols in red wines potently inhibit expression of the vasoconstrictor peptide endothelin-1...
Link Between Education Level and AD Risk Strengthened
A study of the elderly in Sweden provides more evidence that people with a higher level of education are less likely to be diagnosed with Alzheimer's disease or other dementias...
Current Filters
- Date Range : All x