Divergent Roles for PS1, PS2: Not All γ-Secretases Are Created Equal
Presenilins make up the catalytic core of the γ-secretase protease complex, and are infamous for their role in...
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Presenilins make up the catalytic core of the γ-secretase protease complex, and are infamous for their role in...
Prions, those infectious proteins responsible for scrapie, mad cow, and human diseases like Creutzfeld-Jacob, are usually deposited in the brain as...
The term "programmed cell death," and its synonym, "apoptosis," both invoke a vision of...
Though no one is exactly sure why, loss of the ubiquitin carboxy terminal hydrolase UCHL1 appears to be linked to both Alzheimer and Parkinson disease. Now, a paper in this week’s PNAS online raises the intriguing possibility that...
Two years ago, researchers succeeded in breeding fruit flies with mutations in parkin, the gene responsible for most cases of early-onset PD in humans...
The epidemiologic link between elevated blood homocysteine (HC) and Alzheimer disease has spurred the search for the mechanisms by which...
The intramembrane protease activity of γ-secretase is a prime target for therapeutic strategies aimed at treating Alzheimer disease by...
In a brief article in today’s Science, Frederic Mery and Tadeusz Kawecki at the University of Fribourg, Switzerland, report that in fruit flies, at least, making...
Tom Fagan Interviews Howard Fillit
Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show...
In February 2004, researchers at Seoul National University in Korea surprised the world when they reported...
ApoE figures large in Alzheimer disease as the only known genetic risk factor for sporadic AD and an important regulator of...
Immunotherapy, through either passive or active immunization, remains a viable and aggressively pursued strategy for...
A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that...
Adult stem cells in the intestine and skin of mice can be induced to...