BRIdging Alzheimer Disease and British/Danish Dementias
Amyloids can be formed from many different proteins. In Alzheimer disease (AD), amyloid-β (Aβ) is the culprit, but in other diseases it can be...
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Amyloids can be formed from many different proteins. In Alzheimer disease (AD), amyloid-β (Aβ) is the culprit, but in other diseases it can be...
Despite the intense scrutiny of the proteolytic processing and products of the amyloid precursor protein (APP) and its role in Alzheimer disease, the normal function of this...
Oxygen is a double-edge sword for cells: It is necessary for life, but at the same time it is the source of damaging free radicals that attack DNA, proteins and cell membranes...
If a fat-free mouse is just what you need to weigh the impact of lipid biology on Alzheimer disease (AD) or other neurodegenerative diseases, then look no further than...
Normal cellular prion protein (PrPc) is easy to spot on the surface of neurons and glia in the CNS by antibody staining. But when the protein converts...
This week, light from two very different angles was shone on the process of neurodevelopment. Writing in PNAS, researchers described a method to...
Oakland: Food for Thought at American Aging Association Annual Meeting Oakland: Caloric Restriction Set for Primate Time? Oakland: Are Mitochondria the Key to Longevity? American Aging Association: 2005 Annual Meeting
The benefit of caloric restriction (CR) on health and longevity was one of the major themes at the 34th annual meeting of the American Aging Association, held June 3-6 in Oakland, California...
Depending on how you look at it, the brain-residing activated microglia observed in Alzheimer disease could be...
There is now overwhelming evidence in the scientific literature that caloric restriction (CR)...
Prions, the infectious agent of mad cow and Creutzfeldt-Jakob disease in humans, are proteins that form...
The recent emphasis on caloric restriction (CR) as a means to extend lifespan didn’t stop the American Aging Association from...
Presenilins make up the catalytic core of the γ-secretase protease complex, and are infamous for their role in...
Prions, those infectious proteins responsible for scrapie, mad cow, and human diseases like Creutzfeld-Jacob, are usually deposited in the brain as...
The term "programmed cell death," and its synonym, "apoptosis," both invoke a vision of...