Oakland: Are Mitochondria the Key to Longevity?
The benefit of caloric restriction (CR) on health and longevity was one of the major themes at the 34th annual meeting of the American Aging Association, held June 3-6 in Oakland, California...
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The benefit of caloric restriction (CR) on health and longevity was one of the major themes at the 34th annual meeting of the American Aging Association, held June 3-6 in Oakland, California...
Depending on how you look at it, the brain-residing activated microglia observed in Alzheimer disease could be...
There is now overwhelming evidence in the scientific literature that caloric restriction (CR)...
Prions, the infectious agent of mad cow and Creutzfeldt-Jakob disease in humans, are proteins that form...
The recent emphasis on caloric restriction (CR) as a means to extend lifespan didn’t stop the American Aging Association from...
Presenilins make up the catalytic core of the γ-secretase protease complex, and are infamous for their role in...
Prions, those infectious proteins responsible for scrapie, mad cow, and human diseases like Creutzfeld-Jacob, are usually deposited in the brain as...
The term "programmed cell death," and its synonym, "apoptosis," both invoke a vision of...
Though no one is exactly sure why, loss of the ubiquitin carboxy terminal hydrolase UCHL1 appears to be linked to both Alzheimer and Parkinson disease. Now, a paper in this week’s PNAS online raises the intriguing possibility that...
Two years ago, researchers succeeded in breeding fruit flies with mutations in parkin, the gene responsible for most cases of early-onset PD in humans...
The epidemiologic link between elevated blood homocysteine (HC) and Alzheimer disease has spurred the search for the mechanisms by which...
The intramembrane protease activity of γ-secretase is a prime target for therapeutic strategies aimed at treating Alzheimer disease by...
In a brief article in today’s Science, Frederic Mery and Tadeusz Kawecki at the University of Fribourg, Switzerland, report that in fruit flies, at least, making...
Tom Fagan Interviews Howard Fillit
Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show...