A study of Swedish twins, including many over the age of 80, leads researchers to conclude that the genetic contribution to late-onset Alzheimer's disease is not as great as previously estimated...
The research group that originally identified the Parkinson's mutations reveals that DJ-1 may also play a role in the formation of neurofibrillary tangles found in Alzheimer's and of similar bodies...
Reports in the 12 December issue of Cell reveal that post-translational modification of proteins may play a crucial role in two key steps required for protein removal—proteasomal degradation and transportation...
Despite the complications encountered with vaccines for Alzheimer's disease antibody therapy still has potential as a therapeutic. The December 3 Biochemistry reports a new variation on the antibody theme...
Melatonin does not appear to be useful in helping most Alzheimer's patients achieve a good night's sleep, according to a study in the November issue of the journal Sleep...
A case report in the December 5 issue of the New England Journal of Medicine presents an example of the potential dangers of anticholinergic drugs in some patients: short-term memory loss and hallucinations...
New Orleans: Immunotherapy—The Game Is Still in Town New Orleans: New Approaches to Lift Microglia Mysteries New Orleans: Symposium Probes Why Synapses Are Suffering New Orleans: Out Go Classic γ-Secretase Inhibitors, In Come More Dexterous NSAIDs? New Or
At the 33rd Annual Meeting of the Society of Neuroscience held last month in New Orleans, <strong>Bruce Lamb</strong> described the latest analysis of his strains of congenic mice that differ by background only—a novel approach to study AD genetics...
The ubiquitin-proteasome system, which operates in almost every eukaryotic cell, has been implicated in the pathogenesis of numerous neurodegenerative diseases. So does this pathway have a specialized role in neurons?...
The accumulation of protein aggregates is a common theme uniting most major neurodegenerative diseases, but does this phenomenon underscore a common pathogenic mechanism?...
A satellite meeting to the 33rd Annual Meeting of the Society for Neuroscience addressed nicotine and nicotinic receptors, and their potential for Parkinson's disease therapy...
A paper in the December 5 issue of Science offers some clues about the manifold roles that ROS play in signaling pathways during embryonic development...
At the Society for Neuroscience meeting in New Orleans, approximately 100 scientists gathered to discuss what roles the interaction between Aβ and the nicotinic acetylcholine receptor (nAChR) play in normal cognitive function and Alzheimer's disease...