Network Analysis Points to Distinct Effects of Amyloid, Tau
Mice with amyloid plaques develop runaway neuroinflammation, whereas mice with tau tangles predominantly lose synapses, a gene-expression study reports.
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Paper Alert: Astrocyte Receptor Could Hinder Memory
People with Alzheimer’s overexpress the A2A receptor, which suppresses memory in mice.
‘Still Alice’ Gives Voice to Patients with Early Onset Alzheimer’s
Hollywood turns its attention to a rare form of dementia, giving a personal look at the impact of the disease.
Approved Amyloid Imaging Agents Work About Equally Well
All three PET agents demonstrate roughly equivalent abilities to detect brain amyloid, a new analysis finds.
Are Upper Motor Neuron Gaffes a Prelude to Disease?
Upper motor neurons, implicated in many neurodegenerative diseases, are sensitive to both cell stress and hyperexcitability.
Lumbar Puncture: Heading Off the Dreaded Headache
Spinal taps have a bad rap. Are headaches really all that common afterwards, and are there ways to prevent them?
MAPping Death Pathways in Axons
The classic kinase cascade conspires to commit programmed axonal degeneration after injury.
Structure of Microglial Receptor Offers Clues for PET Ligand Design
For the first time, scientists report a crystal structure of TSPO, a potential target for PET imaging of neuroinflammation.
Voilà SorLA! Sorting Receptor’s Structure Solved
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
Human Amyloid Imaging Meeting Was Abuzz With Talk of Tau
The field of tau PET is growing rapidly as the leading tracer T807/AV1451 is more widely used and new compounds from Japan and Switzerland enter the scene with clinical trials of their own.
Human Amyloid Imaging 2015
Human Amyloid Imaging Meeting Was Abuzz With Talk of Tau Tau Tracer T807/AV1451 Tracks Neurodegenerative Progression Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases What If It’s Not Garden-Variety AD? Telling Variants Apart by Where
In Fruit Flies, MicroRNA Protects Synapses Against Excitotoxicity
Loss of the microRNA leads to glutamate toxicity and neurodegeneration.
Tau Tracer T807/AV1451 Tracks Neurodegenerative Progression
Data come tumbling in as more people are getting scans with the first widely used tau PET tracer. Scientists at HAI were pleased by how closely degeneration and symptoms match up in Alzheimer’s.
Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases
Early data suggest that the T807/AV1451 signal relates to cerebrospinal biomarkers of Alzheimer’s, intensifies by up to 10 percent a year, and might nail diagnoses beyond typical AD.
Mixed Bag on Tau Tracer Validation, Kinetics: Some Things Fit, Some Don’t
Autoradiography confirms that T807/AV1451 binds tau but not TDP-43. Even so, some say the tracer will benefit from more technical work to ensure it will measure small changes robustly in multicenter settings.
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