Synaptic Proteins in CSF: New Markers of Cognitive Decline?
Protein levels track with cognitive function and can distinguish Alzheimer’s patients from controls.
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Brain Conference Spotlights Transcriptomics, Therapeutic Strategies
New potential immunotherapies and insight into single-cell responses were highlights of a small meeting in Denmark.
Move Over CSF, P-Tau in Blood Also Tells Us There’s Plaque in the Brain
At this year’s AAIC, no sooner had scientists reported that phospho-tau in the CSF might reflect early responses to amyloid, than they reported parallel data for phospho-tau in blood.
Are Aβ Blood Tests Ready for Prime Time?
A plasma assay for Alzheimer’s could radically speed up screening for clinical trials; alas, competing assays don’t measure the same thing.
Nixing Complement Protein Protects Neurons in Tauopathy Model
In a tauopathy model, knocking out C3 spared synapses and neurons. In an amyloidosis model, deleting C3 preserved dendritic spines, but exacerbated plaque growth.
Healthy Lifestyle Hedges Dementia Risk, but Not if Genetic Risk Runs High
Older people who lived healthy lifestyles had a third lower risk of dementia than their unhealthy peers, but only if their genetic risk for the disease was low.
Refining Models of Amyloid Accumulation in Alzheimer’s Disease
Clinical trial design could benefit from new estimates of how slowly amyloid accumulates and how best to detect it at various disease stages.
Raw Deal: Lose Ataxin, Gain BACE
Loss of ataxin-1 intensifies BACE1 expression, Alzheimer’s pathogenesis. Is that how ataxin GWAS variants increase AD risk?
Technology Brings Dementia Detection to the Home
Smartphones and gamified apps move cognitive testing from the lab into the real world. But keeping people engaged remains a problem. Is passive monitoring the answer?
Smart Homes Open Doors to Insights into Aging, Dementia
Passive monitoring of old people in their everyday lives is starting to generate new indicators for cognitive impairment.
Geneticists Seek Out Rare Contributors to Alzheimer’s
New genes linked to early and late-onset AD offer up mechanistic insight, potential targets for treatment.
Herpesvirus: Trigger for Many Brain Pathologies?
At Quebec conference, researchers considered multiple aspects of herpesvirus biology that may come in to play in AD.
Alzheimer's Association International Conference 2019
New PET Staging Scheme for Amyloid? Physical Activity May Shield the Brain from the Onslaught of Aβ Crenezumab Update: Baseline Data from Colombian Prevention Trial Colombian Cohort Delivers Data on Blood NfL Rare Luck: Two Copies of ApoE2 Shield Against ...
Can Induced Neurons Identify Early Signs of Neurodegeneration?
In patient-derived neurons, tau mutations scupper lysosomes and SORLA shunts APP through different types of endosomes.
Colombian Cohort Delivers Data on Blood NfL
In 2,144 Colombian ADAD family members, plasma NfL in gene carriers rises as early as two decades before their symptoms start.
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