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C9ORF72 Toxicity Tied to Mitochondria, Transcriptional Machinery
In a new, inducible mouse model, poly(GR) damages mitochondria, but its effect is reversible. In flies, turning off transcription of hexanucleotide expansion protects cells.
American Academy of Neurology 2018 Annual Meeting
As RNA Therapies Come of Age, Efficacy Remains Weak At AAN, Sights Set on Antisense Therapies for Diseases of the Brain New Alzheimer’s and Parkinson’s Immunotherapy Data at AAN Will RNA molecules that bump up or tamp down gene expression live up to their ...
Familial Alzheimer’s Mutations: Different Mechanisms, Same End Result
A fleet of patient-derived neurons show that while an APP mutation shifts where γ-secretase takes its first bite, PS1 mutations blunt the enzyme’s second cut. Eventually, all mutations drive up the Aβ42:40 ratio.
Neurogenesis Wanes in Alzheimer’s, Along With Cognition
Research on postmortem human brain strengthens the idea that an ebbing of neurogenesis may underlie cognitive decline.
Anti-Tau Antibody Looks Safe, Hits Target
Phase 1b data show that Biogen’s BIIB092 lowers N-terminal tau fragments in cerebrospinal fluid by more than 90 percent.
Mutant Tau Messes Up Connectivity of Newborn Neurons
In a mouse model of frontotemporal dementia, a trifecta of tau mutations hobbles newborn neurons in the dentate gyrus.
γ-Secretase Revisited—Could Selective Inhibitors Treat AD, Cancer Safely?
A compound that only blocks presenilin 1-containing secretases beat back leukemia in mice—without side effects caused by broad-spectrum inhibitors.
Study Strengthens Link between Hepatitis C Virus, Parkinson’s
In Taiwan, interferon treatment for chronic hepatitis C infection appears to have reduced the incidence of Parkinson’s disease.
Paper Alert: VCAM1 Opens the Door to Brain Aging
Expression of VCAM1 on the endothelial cells that line the blood-brain barrier allowed aging factors in the plasma to exact their toll on the brain.
Chimeric Mice: Can They Model Human Microglial Responses?
By slipping human microglia inside the mouse brain, researchers hope to better monitor their response to pathologies, such as Aβ.
Paper Alerts: Massive GWAS Studies Published
Researchers publish 14 new AD variants. This includes one near WWOX, a gene that encodes a protein linked to tau and lipid metabolism.
Single-Cell Profiling Maps Human Microglial Diversity, Flexibility
Human cells show more phenotypic variation than mouse microglia, but the two match up well overall.
Intelligence Matters More for Brain Reserve, but Education Helps
Longitudinal and genetic studies reveal that intelligence underlies cognitive reserve.
Microglia Reveal Formidable Complexity, Deep Culpability in AD
Many genes that increase risk for late-onset AD are expressed in microglia, and researchers are going cell by cell to unravel the pathways involved in the immune response to amyloid and tau.
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