Not-so-Sweet 16—Kinase Inhibitor Sours Adult Neurogenesis and More
In the September 6 Nature online, a suite of papers reports that age-related loss of regenerative capacity is caused, at least in part, by...
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In the September 6 Nature online, a suite of papers reports that age-related loss of regenerative capacity is caused, at least in part, by...
A paper out today in Cell proposes a novel role for presenilins in calcium signaling...
Just as amyloid-β toxicity may be attenuated by proteases such as insulin degrading enzyme and neprilysin, tau toxicity...
Activation of the pregnane X steroid receptor (PXR) prevents neurodegeneration in a mouse model of the cholesterol metabolic disorder Niemann-Pick C disease...
Last year, four independent research groups reported a linkage between polymorphisms in the complement factor H (CFH) gene to age-related macular degeneration...
A new study previously described in an ARF conference report is bound to draw renewed attention to proteasome dysfunction in Alzheimer disease...
Molecules of the immune system may look a bit out of place on neurons, but they are increasingly revealing themselves as important players in the brain...
In Alzheimer disease and other neurodegenerative disorders, chronic activation of glutamatergic neurons may fuel excitotoxicity and neuronal death...
A new mouse model has achieved a long-sought pathological prize...
The sticky mouse gets its name from the unkempt appearance of its fur, but the animal has more than a cosmetic flaw...
Mutation or duplication of the protein coding sequence of the α-synuclein gene (SNCA) can cause autosomal dominant inherited Parkinson disease, but...
Clearly, the best way to avoid Alzheimer disease is not to grow old. But why?...
Mounting evidence from mouse models points to soluble amyloid-β (Aβ) oligomers as the cause of early, reversible deficits in synapse function and memory...
Using data from a longitudinal study of nearly 2000 Finnish adults, researchers have devised a simple scoring scheme to judge...
The 10th International Conference on Alzheimer’s Disease and Related Disorders, held earlier this month in Madrid, offered its share of data on...