Chew ’em Up and Spit ’em Out: Aβ Leaves Cells via Exosomes
After their production in endosomes, intraneuronal membrane-bound amyloid-β (Aβ) accumulates in multivesicular bodies (MVBs), but...
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After their production in endosomes, intraneuronal membrane-bound amyloid-β (Aβ) accumulates in multivesicular bodies (MVBs), but...
A pair of studies published in the July 6 Neuron show that in two different mouse models of Down syndrome, the cause of neuron death...
Baby boomers joke about forgetting, usually without thinking twice, but are such minor memory lapses just a normal part of the aging process, or could they be a sign of worse things to come?...
What drives the accumulation of amyloid in the brains of Alzheimer patients? There are just two possibilities...
The extension in lifespan achieved by eating fewer calories depends on activation of sirtuins...
Mutations in the presynaptic protein α-synuclein, or even just overexpression, can cause Parkinson disease (PD) by...
Expansion of the polyglutamine (polyQ) tract in the huntingtin protein is necessary to cause Huntington disease, but it is not...
In the earliest stages of Alzheimer disease, Aβ is on the rise, especially in...
A new kinase joins the ranks of those linking a miscreant cell cycle to Alzheimer disease...
The news this week brings four papers describing different approaches to prevent or treat neurodegeneration...
The tumor suppressor and apoptotic transcription factor p53 has been linked to Alzheimer disease in numerous ways, but perhaps the most direct link is...
Just where in the pathogenic process tau deals cells their death blow is a topic of much debate and research. Two studies published this week take a closer look. Brandt et al. report on the effects of a pseudohyperphosphorylated tau mutant in hippocampal slice cultures...
In a paper just out online in Nature Neuroscience, Scott T. Brady et al. report that the polyQ expanded androgen receptor (the cause of spinal bulbar muscular atrophy) inhibits fast axonal transport by activating the c-jun N-terminal kinase (JNK), which phosphorylates the kinesin heavy chain subunit...
Tall Science at Small Retreat: Dispatch from Germany’s Eibsee Oligomers Abound, But Where’s the Seed? γ-Secretase: Ins and Outs of a Voracious Membrane Protein Grinder First Look at the Secretase, New Kid on the Block Assembly, Traffic Escorts, Fats All C
Conclusion of our 11-part Eibsee series.