See How They Grow: Structure of Amyloid-β Fibrils
Current interest in the toxic mechanisms of oligomeric amyloid-β proteins notwithstanding, the larger fibrils this protein forms also are...
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Current interest in the toxic mechanisms of oligomeric amyloid-β proteins notwithstanding, the larger fibrils this protein forms also are...
A high failure rate of new therapeutics during the clinical development process makes drug development a risky business...
Prostaglandin E2 (PGE2) responses could play a role in Alzheimer disease (AD) pathology...
If the amyloid hypothesis can explain Alzheimer disease (AD), can it also explain why some people with AD...
The current issue of Science Magazine is a special issue on neurodevelopment, while the Signal Transduction Knowledge Environment focuses on synaptic plasticity, and the <a href="http://sageke.sciencemag.org/">Science of Aging Knowledge Environment</a> has a Perspective on working memory and selective attention in cognitive aging...
Eight years after researchers showed that mutations in α-synuclein were sufficient to cause Parkinson disease, a clear biological function for this presynaptic protein has...
The development of MRI to scan living brain for amyloid lags behind the impressive progress made recently with the PET-PIB approach, but...
Exactly a year ago, the LRRK2 gene was reported to cause inherited cases of Parkinson disease and, a few months later...
An international crew of investigators called the International HapMap Consortium published their first draft of the human haplotype chart...
A protein that underlies a severe and fairly common neurodevelopmental disease called Rett syndrome has a more sophisticated function than scientists previously suspected...
Keeping brain amyloid-β (Aβ) levels in check means controlling both the means of production and the method of disposal...
In today’s Nature, researchers report that Wnt signaling plays an important role in...
Earlier this month, a study previously reported in our Conference News appeared in PNAS...
This week, a study previously reported in our Conference News appeared in JBC...
Over the past dozen years, great strides have been made in identifying mutations that cause Alzheimer (AD) and Parkinson (PD) diseases. But while...