Mysterious RNA Circles Crop up in Alzheimer’s Brain
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
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PET Identifies Tangles Decades after a Single Traumatic Brain Injury
The pattern varied from person to person, depending on the site of injury, in contrast to the stereotyped distribution of tau tangles seen in Alzheimer’s disease.
In Mice and Men, Prostate Drug Reportedly Treats Parkinson’s Disease
In animal models and patient-derived neurons, terazosin elevated ATP and warded off neurodegeneration. Men who take the drug to control prostate hyperplasia are less likely to get PD, or have milder symptoms.
LRRK2 Mutation Fires Up Immune Response, Harms Brain
The G2019S variant that boosts Parkinson’s risk helps mice survive infection, but raises α-synuclein in the brain and increases neuronal death.
Does Your Personality in High School Foretell Your Dementia Risk?
Based on high school personality tests taken nearly 60 years ago, researchers associated certain traits with future risk of dementia.
Deep Sleep Makes Waves for CSF
Slow-wave sleep brings on coordinated oscillations in blood flow, which in turn are coupled to waves of cerebrospinal fluid. The data point to a mechanism linking deep sleep to the flow of CSF.
Small Molecules Liven Up Lethargic Lysosomes in Parkinson’s Neurons
Two papers used different approaches to energize laggard lysosomal function in neurons derived from people with Parkinson’s. Both restored lysosomal trafficking and reduced α-synuclein accumulation.
Not Just Blood Pressure—Dietary Salt Linked to Tau Phosphorylation
Cognitive deficits in mice on a high-salt diet are due to tau phosphorylation, not reduced blood flow, according to a new study.
Could Getting Enough REST Extend Your Life?
The transcriptional repressor quiets neural activity and lengthens lifespan in worms. It is abundant in the brains of cognitively healthy centenarians.
MRI and Machine Learning Depict Brain Aging in Health, Disease
From more than 45,000 MRI scans, a typical pattern of brain aging emerges. Brains “age” faster in people who have a neurological disorder.
Paper Alert: MS4A Variants May Sway Alzheimer’s Risk Via TREM2
Different polymorphisms in MS4A genes up- or downregulate levels of TREM2, modulating levels of the shed ectodomain in the cerebrospinal fluid and AD risk.
Why Bother With Round Robins on Blood Tests? Q&A with Kaj Blennow
What’s with all those head-to-head comparison studies of academic and commercial biomarker tests? Could we not just pick one that works, and be done?
Nixing Complement Protein Protects Neurons in Tauopathy Model
In a tauopathy model, knocking out C3 spared synapses and neurons. In an amyloidosis model, deleting C3 preserved dendritic spines, but exacerbated plaque growth.
Healthy Lifestyle Hedges Dementia Risk, but Not if Genetic Risk Runs High
Older people who lived healthy lifestyles had a third lower risk of dementia than their unhealthy peers, but only if their genetic risk for the disease was low.
Raw Deal: Lose Ataxin, Gain BACE
Loss of ataxin-1 intensifies BACE1 expression, Alzheimer’s pathogenesis. Is that how ataxin GWAS variants increase AD risk?
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