Paper Alert: VCAM1 Opens the Door to Brain Aging
Expression of VCAM1 on the endothelial cells that line the blood-brain barrier allowed aging factors in the plasma to exact their toll on the brain.
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Chimeric Mice: Can They Model Human Microglial Responses?
By slipping human microglia inside the mouse brain, researchers hope to better monitor their response to pathologies, such as Aβ.
Paper Alerts: Massive GWAS Studies Published
Researchers publish 14 new AD variants. This includes one near WWOX, a gene that encodes a protein linked to tau and lipid metabolism.
Single-Cell Profiling Maps Human Microglial Diversity, Flexibility
Human cells show more phenotypic variation than mouse microglia, but the two match up well overall.
Microglia Reveal Formidable Complexity, Deep Culpability in AD
Many genes that increase risk for late-onset AD are expressed in microglia, and researchers are going cell by cell to unravel the pathways involved in the immune response to amyloid and tau.
Tau Silences, Aβ Inflames; Hitting Excitatory Synapses Hardest
At SfN and in new papers, scientists describe how synapses crater under the combined onslaught of Aβ and tau. They also link gene-expression signatures to the selective vulnerability of excitatory neurons to tau pathology.
TADPOLE Challenge: Winners Forecast AD Symptoms
Using different techniques, contestants vied for the best way to tell which ADNI participants would develop clinical, cognitive, or imaging signs of Alzheimer’s disease.
New Tool: Microglia-Specific Reporter Mice, With Choice of Colors
Two groups create mice for imaging and manipulation of microglia, leaving related cells untouched. The trick? Piggybacking on Tmem119 expression.
Sliced by ApoE Genotype, Whole Exome Data Yield New AD Variants
One rare variant protects ApoE4 carriers, others put noncarriers at risk.
Meet medRχiv: A New Preprint Server for Health Research
Today, the creators of bioRχiv launch a repository for preliminary medical research, including clinical trial data.
Down to Sex? Boy and Girl Microglia Respond Differently
Microglial responses to Alzheimer’s risk variants, and to tau pathology, appear to show a sex difference. Microglia in male versus female mice use different biological mechanisms to maintain homeostasis.
TREM2, Microglia Dampen Dangerous Liaisons Between Aβ and Tau
At a joint Keystone symposia, researchers reported how microglia, via TREM2, compress plaques and rein in the pathogenic distortion of neurites into swollen stubs. Without TREM2, these damaged neuronal processes served as fertile ground for tau propagation.
Dopaminergic Neurons Conjured from Astrocytes Restore Motion
At Keystone, researchers described how directly converting astrocytes into neurons within the mouse striatum restored neuron numbers in a model of PD.
Invading T Cells Quash Neurogenesis
Brains of old mice birth fewer neurons when T cells invade the subventricular zone. The immune cells spew inflammatory cytokines that snuff out neurogenesis.
Epilogue on Edonerpic: It Does Not Work in Alzheimer’s
Drug didn’t slow decline in a Phase 2 trial.
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