The Mutation You Want: It Protects the Brain, Extends Life
A PLCG2 variant that reduces a person’s risk of Alzheimer’s, frontotemporal dementia, and dementia with Lewy bodies also appears to extend longevity.
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Flash! Beep! Gamma Waves Stimulate Microglia, Memory
Exposing AD mice to multisensory gamma therapy induced 40-Hz waves in their brains, plus effects on amyloid, tau, microglia, blood vessels, and cognitive function.
Parsing Local and Distal Aβ Shows Links to Metabolism, Cognition
Aβ deposits make distal neurons vulnerable to insults, including from local Aβ, says imaging study. The combination hastens cognitive decline.
Wild Mice Inject Genetic Diversity into Models of Alzheimer’s Disease
New strains have amyloid, neurodegeneration, and neuroinflammation, all against a background of natural genetic variation.
Aβ Dimers Block Glutamate Uptake, Fire Up Synapses
New evidence suggests the dimers impede clearance of glutamate from synapses, contributing to the hyperexcitability seen early in Alzheimer’s disease.
ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome
The phenotype of ApoE4 astrocytes and microglia resembles that of these cells in Alzheimer’s brain. Could defects in lipid metabolism and the extracellular matrix bring on the disease?
Islands of Tau Coat and Protect Cytoskeleton
The protein forms cohesive rafts along microtubules, protecting them from digestion and regulating movement of molecular motors.
Are Microglia Plaque Factories?
Eliminating microglia in a mouse model of amyloidosis nearly abolished parenchymal plaques, but led to a huge buildup of amyloid in cerebral blood vessels.
Brainstem GABAergic Inputs to Hippocampus Control Memory Formation
The locus incertus fine-tunes hippocampus neural activity to control memory formation in stressful situations. Could a new understanding of these circuits shed light on memory loss in Alzheimer’s?
Hello Mitochondriomics: Tagging Method Identifies Different Subtypes
The organelles express unique sets of proteins depending on their environment. Astrocyte mitochondria process lipids better than those in neurons.
Tiny Brain Structure Plays Big Role in Memory
New data strengthen the idea that a healthy locus coeruleus keeps memory sharp into old age.
Among AD Mutations, Only ApoE4 Seems to Hobble Microglia
In induced human microglia, the E4 allele profoundly affected their health and cellular responses, while familial Alzheimer’s mutations had little effect.
In Pathology Cascade, Microglia Rev Up After Plaques but Before Tangles
Amyloid plaques in postmortem human cortex correlated with the proportion of microglia that were activated, not with microglial numbers. Tau pathology and cognitive decline come later.
Serial PET Nails It: Preclinical AD Means Amyloid, Tau, then Cognitive Decline
Serial amyloid and tau scans in cognitively healthy people indicate that the speed at which a person’s tau accumulates best predicts his or her future cognitive decline.
Forget Fibrils: Lewy Pathology Is More Lipid Than Protein
An electron microscopy study reveals a jumbled mess of membrane chunks and malfunctioning organelles, bound together by phosphorylated or truncated α-synuclein.
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