Brain-Wave Patterns Distinguish Parkinson’s Subtypes
Neural-wave patterns could help clinicians guide electrodes for deep-brain stimulation.
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In C9ORF72 Expansion Carriers, Protein Levels Drop in Cerebellum
A batch of new monoclonal antibodies against the C9ORF72 protein also revealed the protein lingers in presynapses.
Technology for Patients: Purring Robots, Digital Data-Gathering
AAIC showcased advances in scientists’ attempts to integrate technology into dementia care and research. This includes the use of furry robot seals to keep patients company.
Flortaucipir Meets Primary Endpoints in Phase 3 Autopsy Trial
PET tracer predicts tau pathology and AD, according to company press release.
Let ’Er RIP: ALS/FTD Variant Plus Aging Unleash Deadly Kinase
Loss-of-function mutations in TBK1 combined with age-related dearth of an analog spell trouble for motor neurons and the central nervous system.
Tangles Turn Neuronal Membranes Inside Out, Give Microglia License to Eat Their Fill
Tau-laden neurons present a phospholipid “eat me” signal, bidding microglia to devour them alive.
Are Tauopathies Caused by Neuronal and Glial Senescence?
Removing senescent cells from mouse brain ameliorates the effects of mutant human tau.
Does APP Promote Synapse Loss, Aβ Production Through Wnt Signaling?
A Wnt pathway inhibitor rescued dendritic spines in cultured neurons and cleared plaques in an AD mouse model.
New Antibody Binds to Mid-Region, and Aggregates, of Tau
X-ray crystallography yields high-resolution structure.
In Entorhinal Cortex, Histone “Acetylome” Bears Mark of Alzheimer’s Disease
In AD brain, scientists see a genome-wide histone acetylation pattern replete with peaks near familiar AD genes such as APP, presenilin, tau, complement receptor, and more.
TDP-43 Joins Cell-To-Cell Propagation Gang
Much like tau, Aβ, and α-synuclein, pathological TDP-43 spreads through the mouse brain, following the trail of neuronal connections and corrupting healthy protein along the way.
Autopsy Study Confirms Flortaucipir PET Lights Up Tau Pathology
Case study in early onset AD finds PET ligand tracks regional tau burden.
Model Morass? R47H Mutation Scuttles TREM2 Expression in Mice, Not People
A new finding questions the usefulness of some mouse models.
TDP-43: Separating Physiological Wheat from Pathological Chaff
A new technique helps researchers single out and characterize toxic aggregates of TDP-43 from human brain.
Local Flavor: At Protein Level, Too, Human Microglia Are Diverse
Multiplexed marker analysis in single cells from human brain corroborates expression data, identifies microglia subsets in human brain.
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