Neural-wave patterns could help clinicians guide electrodes for deep-brain stimulation.
A batch of new monoclonal antibodies against the C9ORF72 protein also revealed the protein lingers in presynapses.
AAIC showcased advances in scientists’ attempts to integrate technology into dementia care and research. This includes the use of furry robot seals to keep patients company.
PET tracer predicts tau pathology and AD, according to company press release.
Loss-of-function mutations in TBK1 combined with age-related dearth of an analog spell trouble for motor neurons and the central nervous system.
Tau-laden neurons present a phospholipid “eat me” signal, bidding microglia to devour them alive.
Removing senescent cells from mouse brain ameliorates the effects of mutant human tau.
A Wnt pathway inhibitor rescued dendritic spines in cultured neurons and cleared plaques in an AD mouse model.
X-ray crystallography yields high-resolution structure.
In AD brain, scientists see a genome-wide histone acetylation pattern replete with peaks near familiar AD genes such as APP, presenilin, tau, complement receptor, and more.
Much like tau, Aβ, and α-synuclein, pathological TDP-43 spreads through the mouse brain, following the trail of neuronal connections and corrupting healthy protein along the way.
Case study in early onset AD finds PET ligand tracks regional tau burden.
A new finding questions the usefulness of some mouse models.
A new technique helps researchers single out and characterize toxic aggregates of TDP-43 from human brain.
Multiplexed marker analysis in single cells from human brain corroborates expression data, identifies microglia subsets in human brain.