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The Calpain Connection

The cysteine protease calpain cleaves the cdk5 regulator p35, releasing a 25KD fragment that accumulates in the brains of people with Alzheimer’s disease. What’s more, Aβ42 is among the factors...

Slowing the Scrapie Prion

According to a report in today's Science, a productive approach to combating the spongiform encephalopathies such as the transmissible "variant" Creutzfeldt-Jacob disease may be to attack cells in the spleen where...

Do Aβ and APP Team up to Kill Neurons?

Many researchers believe that the amyloid-β peptide is a culprit in the neurodegenerative process of Alzheimer's disease. Indeed, they can marshal good evidence that the fibrillar form of Aβ kills neurons in a petri dish...

Another Fatal Peptide from APP

Some of the attention focused on amyloid-β may have to be diverted to yet another peptide product of amyloid precursor protein (APP). Daniel Lu, Edward Koo and colleagues report in the April issue of Nature Medicine that...

Chlamydia Update

Researchers from the Medical University of Lubeck in Germany say that they have failed to replicate the tantalizing evidence from a study published two years ago that found <em>Chlamydia</em> in almost all the Alzheimer's brains examined...

Receptor Miscegenation

Conventional wisdom has it that each member of the large G protein-coupled receptor (GPCR) family pairs up exclusively with another of its own kind. But a new study in tomorrow's Science reports that two different GPCRs...

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