A dynamic joint meeting dispels some old tenets while charting new avenues for research, such as microglia from iPSCs.
Healthy neurons tell astrocytes how to act. In the case of ALS, astrocyte signals spell trouble.
Recent studies exemplify the burgeoning array of stem cell strategies to treat neurodegeneration, ranging from sending in supportive cells to switching out neurons.
People with Alzheimer’s overexpress the A2A receptor, which suppresses memory in mice.
Tiny secreted vesicles emerge as important players in communication between brain cells. Are they important in neurodegeneration?
Trophic factor may rejuvenate aging cells and protect neurons.
A drug that inhibits the sodium/potassium pump rescues a mouse model of the disease.
Researchers are increasingly branching out from their old focus on Aβ and tau to understand how these proteins intersect with physiological processes and new genetic regulatory mechanisms in the aging brain.
Astrocytes kindle neuronal hyperexcitability in mouse models of Huntington’s.
In a cell culture system, astrocytes from people with ALS kill motor neurons. The model could yield more discoveries about the fundamental biology of this disease.
The experimental drug NitroMemantine protects synapses from Aβ oligomer toxicity in mice by blocking extrasynaptic NMDA receptors.
When leaky blood vessels damage the brain, the organ’s stem cell niche dispatches a specialist crew of astrocytes to stop the bleeding...
Pericyte-enwrapping blood vessels near a spinal lesion will differentiate and move toward the injury, forming the core of an astrocyte-coated scar...
Researchers at the University of Wisconsin-Madison have cooked up a method to nudge pluripotent stem cells all the way to astrocytes...
Rather than perish en masse for neuropathological analyses or face behavioral tests ad nauseum, some Alzheimer’s mouse models can get off a tad easier...