Could Neutrophils Be the Newest Players in Neurodegenerative Disease?
Preventing these peripheral phagocytes from creeping into the brain improves memory and ameliorates pathology in mouse models of Alzheimer’s.
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Study Suggests Respiratory Pacemaker Reduces ALS Survival
In a clinical trial, people who used the surgically implanted breathing-assist device died nearly a year sooner than those who used only an oxygen mask.
γ-Secretase Revealed in Atomic Glory
Researchers have generated the first atomic-level structure of γ-secretase. The new view revealed interactions between amino acid residues and the locations of familial Alzheimer’s disease mutations.
ALS Gene Repeats Obstruct Traffic Between Nucleus and Cytoplasm
Three studies report that the C9ORF72 expansion prevents RNAs and proteins from shuttling properly between nucleus and cytosol.
Do Sleeper Viruses Awaken in ALS?
The genetic relics of ancient, dormant retroviruses pepper the human genome. One such virus reanimates in about one-third of ALS cases.
G-Protein Receptor Knockout Rescues Several Models of Alzheimer’s
Ablating Gpr3 reduced amyloid burden and improved memory in various AD mouse models. Researchers propose using Gpr3 inhibitors to treat AD.
Does the Blood-Brain Barrier Stand Up to Alzheimer’s? Study Finds No Breach
The blood-brain barrier barred passage of antibodies in multiple mouse models of neurodegenerative disease, suggesting it holds up well in the face of disease.
Protecting Proteasomes from Toxic Tau Keeps Mice Sharp
In transgenic mice, revving up proteasome function lowered tau deposits and improved memory.
Cancer Drug Clears Plaque, Improves Mouse Memory
An immunotherapy drug recruits immune cells to the brain, where they help clean up amyloid plaques.
Replication a Challenge in Quest for Alzheimer’s Blood Test
Researchers failed to confirm a high-profile, previous 10-lipid panel, but remain bullish on the potential of blood-based metabolites as biomarkers.
It’s All in the Packaging: Better Delivery Renders HDAC Combo Effective in Mice
Caging an HDAC inhibitor in a lipid chelator raised plasma and brain concentrations of the drug and doubled the lifespan of a mouse model of Niemann-Pick type C disease.
Mexiletine Banishes Muscle Cramps in Phase 2 Trial of ALS
Scientists wonder if the sodium channel blocker might also slow disease progression.
Acetylated Tau Mucks Up Memories
The modified protein prevents the synaptic protein KIBRA from managing plasticity.
Can’t Degrade That Pesky Misfolded Protein? Push It Off the MAPS
Not exosome, not proteasome, not autophagy: Could a new pathway dubbed MAPS facilitate the spread of amyloidogenic proteins?
In First Phase 3 Trial, the Tau Drug LMTM Did Not Work. Period.
Claims of a positive effect in a small subgroup of patients are statistically meaningless, experts say.
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