Can Aβ Seeds Be Transferred During Neurosurgery?
Researchers claim that young cases of cerebral amyloid angiopathy may have been caused by contaminated surgical equipment.
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Cannabinoid Receptors and AD: Searching Beyond the Simple Story
Researchers from Spain describe changes in cannabinoid receptors in the brains of AD patients, as well as...
Confirmed: Human Pituitary Extract Linked to Amyloidosis Contains Aβ Seeds
The material, previously used to treat children with growth deficiencies, triggered amyloid deposition in transgenic mice.
AD Clinical Pipeline: Immunotherapy Woes, Dimebon Boons
Two papers in the 19 July Lancet bring both dismay and hope to the ongoing quest for more effective AD treatments...
BACE and γ-Secretase Form Mega-Complex that Processes APP
Are high-molecular-weight, multi-protease complexes cellular Aβ factories?
AMPA Receptors: Going, Going, Gone in Aβ-exposed Synapses, PSD95 Knockouts
One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that...
SfN: The Old and the New—BACE and Cathepsin B Share the β-secretase Stage
A lively platter of slide talks on APP processing and β-secretase (BACE) activities yielded a few interesting tidbits on the...
Dangerous Liaisons—Tau and Aβ, Together at Last?
They are no match made in heaven, but in neurons, the two proteins responsible for amyloid plaques and neurofibrillary tangles might...
Hot DAM: Specific Microglia Engulf Plaques
The transcriptomes of single immune cells in the mouse brain identify specific disease-associated microglia (DAM), which eat away at Aβ deposits.
Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80
Scientists propose that LATE is a neurodegenerative disease marked by TDP-43 pathology in limbic regions, and memory loss. After death, it can be seen alone or with other pathology.
Do World Trade Center Responders Get Early Onset Plaques and Tangles?
Middle-aged WTC responders have cognitive problems, which correlate not only with their PTSD symptoms and exposure to toxic dust, but also with biomarkers of amyloid and tau.
Plaques, Tangles Throw Off the Brain’s Rhythms
In the human brain, alpha waves fell out of sync, while delta-theta waves swelled in concert with amyloid plaques, neurofibrillary tangles. Alpha modulation correlated with cognitive decline.
Tackling Alzheimer’s from the Outside In
Feeling good on the outside often helps us feel good on the inside. Could the same be true for neurons?...
It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
Researchers induced cortical organoids to grow their own vasculature and even form a blood-“brain” barrier, making the little blobs more useful for studying disease.
Does Second X Chromosome Boost Women’s Resilience Against Alzheimer’s?
In female mice it’s the other X chromosome, not lack of a Y, that extends life and preserves memory in the face of amyloidosis. A histone demethylase gene partly explains this. It protects people, too.
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