U.S. Study Says Lithium in Tap Water Does Not Fend Off Dementia
Prior evidence for protective effect evaporates after adjustment for demographic differences in high- and low-lithium communities.
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CryoEM γ-Secretase Structures Nail APP, Notch Binding
First look at substrate interactions reveals similarities but some surprises.
Closing the Book on NSAIDs for Alzheimer’s Prevention
The latest effort to determine if a non-steroidal anti-inflammatory drug protects against Alzheimer’s posted negative results. Time to abandon the approach?
Anatomy News Flash: Brain Drains Lymphatic Fluid Through Its Base
In mice, the back of the brain, near the neck, contains lymphatic vessels that are specialized to take up cerebrospinal fluid and deliver it to cervical lymph nodes.
A Central Role for Prion Protein in Neurodegeneration?
Researchers implicate PrP in the toxicity of Aβ, tau, and α-synuclein oligomers in several neurodegenerative diseases.
Blunt Instruments: α-Synuclein Antibodies Poorly Distinguish Forms
A survey of 16 purported conformation-specific antibodies found that most bound nearly equally well to oligomers and fibrils, and weakly to monomers.
New Data Questions Herpes-Alzheimer’s Connection
A large multinational epidemiology study finds only small and inconsistent associations.
Lithium Hinders Aβ Generation, Buffing Up GSK as Drug Target
The widely used psychiatric drug lithium, and other agents that inhibit glycogen synthase kinase-3 (GSK3), have been mentioned as possible Alzheimer's disease therapies for some time, primarily because GSK3 is one of several kinases known to phosphorylate tau...
Atorvastatin, Vaccine Trial Data Published
A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that...
Love a Good Fight? Check Out Brouhaha Over Amyloid Imaging
As the first of a suite of PET β amyloid imaging agents stands poised to receive a ruling from the FDA, seven scientists are questioning the validity of this technology...
Presenilins Open Escape Hatch for ER Calcium
A paper out today in Cell proposes a novel role for presenilins in calcium signaling...
APP Double Dose Causes Early Onset AD
For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus...
Chicago: Out of the Blue—A Tau-based Treatment for AD?
Of all clinical trials reported at the ICAD, one targeting the protein tau was the <em>therapy du jour</em>...
Alzheimer’s Vaccine: In Some Patients, at Least, It Might Just Work
After a tough year, during which believers in immunotherapy for Alzheimer’s disease have had to fend off vociferous criticism, the news now appears to pick up...
Los Angeles: People With Memory Loss Speak for Themselves
On Saturday, 27 October, in Los Angeles, an unusual conference marked a paradigm shift in the Alzheimer disease movement...
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