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"Mad Yeast"?

This week Peter Chien and Jonathan Weissman of the University of California, San Francisco, explain how they used two species of yeast (and an artificial yeast prion protein to investigate how prions jump the species barrier...

Amyloid Not an Aberration?

Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations...

β-Secretase a Clean Therapeutic Target

The most promising target for an Alzheimer's therapy in the short term may be the enzyme β-secretase, suggest two papers in the March issue of Nature Neuroscience. Two separate groups have found that mice lacking the BACE1...

Exelon Dose Revised

According to a "Dear Healthcare Provider" letter dated January 26 and posted this week on the Web site of the U.S. Food and Drug Administration, patients who take breaks in Exelon...

Neprilysin Steps out of the Shadows

The enzyme neprilysin—capable of degrading Aβ42 peptide—is a new player in the Alzheimer's disease mystery. Writing in Neuroscience Letters, Patrick McGeer's group at the University of British Columbia adds critical circumstantial evidence...

American Society for Cell Biology: 40th Annual Meeting

News Summary from the 40th Annual Meeting of The American Society for Cell Biology Part II: News Summary from American Society for Cell Biology Meeting American Society for Cell Biology: 2000 Annual Meeting ...

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