Can Induced Neurons Identify Early Signs of Neurodegeneration?
In patient-derived neurons, tau mutations scupper lysosomes and SORLA shunts APP through different types of endosomes.
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Ready or Not: Stem Cell Therapies Poised to Enter Trials for Alzheimer’s
At Duke University, researchers discussed how injected stem cells might be tracked and used to treat neurodegenerative diseases.
Shiny SEQUIN: New Technique Counts Synapses Over Large Brain Volumes
Using a form of confocal microscopy and automated software, the method allows researchers to rapidly identify functional synapses within brain structures.
FDA Approves Edaravone for Treatment of ALS
The drug slows functional decline in patients with mild disease and should be available to U.S. patients in August.
After a Summer of Icy Showers, What Will Happen with Buckets of Cash for ALS?
The ALS Ice Bucket Challenge has yielded more than $100 million—what research projects should get a share of the action?
Diagnosis and Prognosis in the “Other” Motor Neuron Diseases
Amyotrophic lateral sclerosis, already a rare condition affecting one to three people in 100,000, nonetheless garners most of the attention in the field of motor neuron disease...
Disadvantaged Neighborhoods Raise Odds of Alzheimer’s
People who lived in impoverished neighborhoods in their last year of life had greater odds of having died with AD neuropathology.
Does Common Structure Explain Cross-Seeding of Fibrils?
Islet amyloid protein and Aβ fibrils share similar folds.
Meet the New Progressive Tauopathy: CTE in Athletes, Soldiers
Prompted by striking brain pathology in both contact sport athletes and military veterans, scientists are now defining a new disease...
RBFOX1 Gene Tied to Amyloidosis in Preclinical Alzheimer’s
Researchers used PET scans from 4,000 people to link RBFOX1 risk variants to amyloidosis. People with lower RBFOX1 expression in their brains had more amyloid and worse cognition.
Primary Tauopathies Get New PET Ligands
Autopsy data confirm that current tau PET tracers are unsuitable for some primary tauopathies. CryoEM structures help researchers find new ligands for tau and α-synuclein.
Tau PET: The Field Expands Rapidly
At the HAI 2020 conference, the tracers PI-2620 and APN-1607 appeared to bind frontotemporal dementia tau. MK-6240 looked highly sensitive. And JNJ-067 and SNFT-1 are two new kids in town.
GABA-A Receptor Structures Point to Drug Mechanisms
CryoEM helps explain how the inhibitory receptors open and close their ion channels.
Liver Enzyme Levitates with Exercise, Spurs Learning in Old Mice
The findings hint at a liver-brain axis that transmits inflammation from periphery to brain, and could suggest therapeutic targets for preserving brain function.
PET Tracer PI-2620 Detects 4R Tau Deposits
The tracer distinguished people with progressive supranuclear palsy from controls with a sensitivity of 85 percent, suggesting potential as a diagnostic for 4R tauopathies.
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