1998 Society for Neuroscience Meeting: α2-Macroglobulin
AD is now widely considered to be a multifactorial disease with only a few dominant genetic mutations that can be considered as directly causing the disease, i.e., APP and the presenilins...
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New Path for Aspirin
It is known that aspirin and sodium salicylate suppress inflammation by inhibiting cyclooxygenase, an enzyme that triggers production of prostaglandin. It has been suspected that these compounds...
Humans Sprout New Neurons
It has long been a dogma of neuroscience that the human brain is born with all the neurons it will ever have, and that those neurons must endure for a lifetime. But evidence has been accumulating...
Stem Cells Take a Leap Forward
The idea of treating developmental and neurodegenerative disorders by growing new brain cells has taken a major step forward, according to results of two studies...
Neuronal Loss in Mouse Model?
Can transgenic mice serve as a truly useful model for studying Alzheimer's disease? Studies of mice expressing an APP gene mutation that causes a form of familial AD have reported no neuronal loss...
Mutant PS1 Destabilizes β-Catenin
Since the discovery that mutations in the gene for PS1 cause familial Alzheimer disease, there has been keen interest in investigating the mechanism by which PS1 mutations cause disease...
Soccer Bad for Brain
A study published in last month's Neurology reports that professional soccer players are at significantly higher risk for long-term brain injuries that affect their mental function...
Eat That Spinach!
A diet rich in certain fruits and vegetables is known to protect against cancer and heart disease, and now a new animal study suggests nutrition can also stall the decline of brain function...
Estrogen Reduces Parkinson's Risk
Estrogen has been shown in recent years to be a possible protective factor in Alzheimer disease, and now new studies suggest it may also protect against the risk of Parkinson's disease...
APP Enhances Mouse Memory
Secreted forms of amyloid precursor protein (APP) may play an important role in the formation and consolidation of memory, according to a study published in today's proceedings of the National Academy of Science...
Neurological Disease Institute Launched at UCSF
A research center focusing on advancing scientific understanding of brain disorders such as Alzheimer's disease, HIV dementia and stroke, was inaugurated earlier this month at UCSF...
Nature Online
The British science journal Nature announced that it is becoming a "full-fledged" electronic journal beginning with this week's issue (at <a href="http://www.nature.com">http://www.nature.com</a>)...
Casting Doubt on Role of Oxidative Damage in ALS
Mutations in the enzyme for superoxide dismutase (SOD1) have been linked to 15 tp 20 percent of cases of amyotrophic lateral sclerosis (ALS), leading to a theory that the disease results when the defective enzyme allows super oxide radicals to build up...
PAK-3 Implicated in Mental Retardation
A mutation in the gene for PAK-3, a molecule that is thought to play a variety of roles in the nervous system, has been implicated in a form of X-chromosome-linked mental retardation...
CPG15: An Activity-dependent Neuronal Growth Promoter
Neuronal growth and synapse formation is regulated by a combination of activity-independent and activity-dependent mechanisms. In today's Science, E. Nedivi et al. describe CPG15, a molecule that enhances dendritic arbor growth...
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