γ-Secretase Revisited—Could Selective Inhibitors Treat AD, Cancer Safely?
A compound that only blocks presenilin 1-containing secretases beat back leukemia in mice—without side effects caused by broad-spectrum inhibitors.
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Study Strengthens Link between Hepatitis C Virus, Parkinson’s
In Taiwan, interferon treatment for chronic hepatitis C infection appears to have reduced the incidence of Parkinson’s disease.
Paper Alert: VCAM1 Opens the Door to Brain Aging
Expression of VCAM1 on the endothelial cells that line the blood-brain barrier allowed aging factors in the plasma to exact their toll on the brain.
Chimeric Mice: Can They Model Human Microglial Responses?
By slipping human microglia inside the mouse brain, researchers hope to better monitor their response to pathologies, such as Aβ.
Paper Alerts: Massive GWAS Studies Published
Researchers publish 14 new AD variants. This includes one near WWOX, a gene that encodes a protein linked to tau and lipid metabolism.
Single-Cell Profiling Maps Human Microglial Diversity, Flexibility
Human cells show more phenotypic variation than mouse microglia, but the two match up well overall.
Intelligence Matters More for Brain Reserve, but Education Helps
Longitudinal and genetic studies reveal that intelligence underlies cognitive reserve.
Microglia Reveal Formidable Complexity, Deep Culpability in AD
Many genes that increase risk for late-onset AD are expressed in microglia, and researchers are going cell by cell to unravel the pathways involved in the immune response to amyloid and tau.
Tau Silences, Aβ Inflames; Hitting Excitatory Synapses Hardest
At SfN and in new papers, scientists describe how synapses crater under the combined onslaught of Aβ and tau. They also link gene-expression signatures to the selective vulnerability of excitatory neurons to tau pathology.
Oligodendrocytes Seem to Imprint Specific Alter Ego on α-Synuclein
Aggregates that form inside, or just pass through, oligodendrocytes take on the properties of the virulent strain that gives rise to multiple system atrophy.
With Sudden Progress, Blood Aβ Rivals PET at Detecting Amyloid
At AAIC, competitors vied for advantage, and discussion moved swiftly to the issue of assay standardization.
TADPOLE Challenge: Winners Forecast AD Symptoms
Using different techniques, contestants vied for the best way to tell which ADNI participants would develop clinical, cognitive, or imaging signs of Alzheimer’s disease.
New Tool: Microglia-Specific Reporter Mice, With Choice of Colors
Two groups create mice for imaging and manipulation of microglia, leaving related cells untouched. The trick? Piggybacking on Tmem119 expression.
Sliced by ApoE Genotype, Whole Exome Data Yield New AD Variants
One rare variant protects ApoE4 carriers, others put noncarriers at risk.
Meet medRχiv: A New Preprint Server for Health Research
Today, the creators of bioRχiv launch a repository for preliminary medical research, including clinical trial data.
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