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The aggregating protein called agrin is a component of two quite different types of synapses: synapses in the neuromuscular junction and the immunological synapse between T cells and antigen-presenting cells...
The Journal of Alzheimer's Disease has awarded the 2001 Alzheimer Medal to Luciano D'Adamio for his article, "Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid-β protein precursor,"...
Permanent memories are thought to be stored in the cortex, but little is known about the processes that incorporate memories into cortical . Now Alcino J. Silva and colleagues, have discovered a molecular manipulation that affects memory...
The path from identifying a genome sequence to pinpointing the contribution of each gene is beset with pitfalls. In a Brief Communication [in today's Nature], researchers describe discrepancies...
Stem cells from the bone marrow of adults may be as flexible as embryonic stem cells, according a study in the current issue of Cell. Researchers at Yale, New York University, and Johns Hopkins found that these cells...
In a prime example of what science can accomplish in the "post-genomic" era, researchers have pieced together the functions of a variety of genes involved in a yeast metabolism pathway...
Two reports in tomorrow's Science add to a growing body of evidence that glial cells play more than a "housekeeping" role and are essential for neuronal signalling...
A closer look at mitochondria in Alzheimer's disease confirms that oxidative damage to these cellular power plants is a central feature of the disease, according to a report in the May 1 issue of the Journal of Neuroscience...
A major challenge for achieving nerve regeneration following an injury to the adult brain and spine is the presence of numerous proteins that block the growth of axons across the injury site...
Researchers from France reported success in synthesizing novel compounds that specifically target γ-secretase cleavage of amyloid-β (Aβ) peptide, without affecting the enzyme's cleavage of other substrates...
Immune Network Ltd. reported last week that the company's Canadian Phase I clinical study has been halted due to an unexplained...
Stem cells from mouse bone marrow can help repair muscle killed in heart attacks, Piero Anversa and his team at New York Medical College, New York, and colleagues, show in [the 5 April issue of] Nature...
A team at Dartmouth College, New Hampshire, has developed a brain-image repository that will make it possible for scientists to freely share fMRI data with colleagues worldwide...
Chris Weihl Interviews Sam Gandy
The abnormal form of the protein huntingtin may exert its toxic effects on neurons in Huntington's disease by interfering with a protein essential for gene transcription, according to a study published in this week's issue of Science...
