Cleaning up Aβ
Insulin-degrading enzyme (IDE) plays a role in breaking down Aβ outside of neurons, report Dennis Selkoe, Konstantinos Vekrellis, and their colleagues at Harvard in the March 1 issue of the Journal of Neuroscience...
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Another AD Link to Inflammatory Processes
For more than a decade, a case has been building for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease. Now researchers say they have found definitive evidence...
MRI Captures Gene Expression
A team led by Thomas Meade at the California Institute of Technology has developed an MRI contrast agent that is activated only in the presence of a target gene, according to a report in the March issue of Nature Biotechnology...
New Memory Cells from the Hippocampus?
Circumstantial evidence has accumulated over the last decade that there are pluripotent stem cells in the hippocampus of humans and other animals. Much hope has been attached to these heretofore elusive cells because...
Down's Syndrome Mouse Model Shows Facial Deformities
The Ts65Dn mouse developed at the Jackson Laboratory in Bar Harbor, Maine, has the signature skull and facial deformities of Down's syndrome, strengthening its case as a model for the human syndrome...
Estrogen Does Not Affect AD Progression
Previous studies have shown that women who take estrogen reduce their risk of developing Alzheimer’s disease. But can estrogen also benefit women who already have been diagnosed with the disease?...
Making Do Without NMDA Receptors
Memory deficits due to NMDA receptor loss in the hippocampus can be overcome by enriched environments, according to a report from Joe Tsien and his Princeton colleagues in the March issue of Nature Neuroscience...
α-Synuclein Transgenic Mice Show Parkinson-like Pathology
Several neurodegenerative diseases, including Alzheimer's, Parkinson's and Lewy body disease, are characterized by abnormal neuronal inclusions of α-synuclein, one of the brain's synaptic proteins...
How Does Calorie Restriction Extend Life?
One part of the answer to this question may involve the yeast nuclear protein Sir2, according to a study in tommorow's issue of Nature. Leonard Guarente, Shin-ichiro Imai and their coworkers at MIT say the protein is regulated by NAD...
Unmasking Gene Mutations: One in the Hand Is Better
Genetic tests based on polymerase chain reactions often fail to detect mutations when both a mutant and a wildtype gene exist in the genome. The key to "unmasking" the mutant allele...
Death Takes a Different Cell Route
A caspase protease in the endoplasmic reticulum (ER) may have a hand in cell death in Alzheimer's, according to a report in the January 6 issue of Nature. The caspases appear to play critical roles in various apoptotic mechanisms...
Prion Parts Can Infect Other Proteins
The essential "prion-determining" portion of a prion protein can be removed and fused to a wholly separate protein, creating a new prion with the essential prion qualities of state changing and heritability...
Early Transcriptional Changes in a Trinucleotide Repeat Disorder
Some of the earliest cellular changes of the trinucleotide repeat disorder spinocerebellar ataxia type 1 (SCA1) appear only one day after the mutant gene that causes the disorder begins to be expressed...
Latest Techniques in Targeting Alzheimer's
A transcript of Bio Online's panel discussion on January 12 is now available...
Why Is an Enterovirus Hiding out in ALS Spinal Cords?
As with many neurodegenerative diseases, viruses have waxed and waned in popularity as possible causative agents in amyotrophic lateral sclerosis (ALS, known as Lou Gehrig's disease in the U.S.)...
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