Can Exercise Protect People Whose Plasma Tau Is Up?
Among old people with high total tau levels in plasma, cognition slid far less in those who are active than in their inactive peers. Could blood tests motivate at-risk people to exercise?
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Among old people with high total tau levels in plasma, cognition slid far less in those who are active than in their inactive peers. Could blood tests motivate at-risk people to exercise?
Decades before tangles become rampant, the biomarker p-tau231 rises in both CSF and plasma. More surprising: neuroinflammation markers do, too.
Topline results from a Phase 2 trial of semorinemab suggest the therapeutic antibody may have eased the cognitive downturn in people with mild to moderate Alzheimer’s disease.
Aβ oligomers rev up glutamate release, depressing synapses for the long term. This instigates the pathological phosphorylation of tau.
Markers of neuronal injury rose in plasma within a few months of severe COVID-19, then fell back to normal by six months. Some cases with brain symptoms had lower Aβ and higher tau in their blood.
North Carolina and South Texas centers to focus on risk factors and diversity.
Large study confirms that insufficient sleep correlates with amyloid accumulation in otherwise healthy adults. Too much sleep is also bad, but for different reasons.
Higher Aβ42 in these neurons correlated with greater plaque load and cognitive decline in their 53 donors, suggesting amyloid overproduction in sporadic AD.
Tau oligomers ensnare an RNA-binding protein and its partner, a type of methylated RNA, in the cytosol of neurons. This triad stresses the cells, leading to neurodegeneration in mice. In people, tau draws in more methylated RNA as Alzheimer's pathology worsens.
This latest and largest GWAS identified 38 risk loci. The seven new ones highlight aging microglia, protein catabolism, and the LilR protein family.
Misfolded tau travels from a subset of neurons in the entorhinal cortex directly into CA1 neurons in the hippocampus, fouling synaptic transmission and memory in mice.
Centenarians had nearly as many pathogenic variants as controls, but they also sported protective variants in insulin and AMPK signaling genes—longevity pathways known from animal models. Functional variants in the Wnt pathway counteracted damage from ApoE4.
In an aging cohort, weak LC signal intensity on MRI correlated with plaques, tangles, and memory problems.
With initial funding secured, DAC is attempting to link Alzheimer's research cohorts, support global clinical trials, and prepare health-care systems around the world.
Amyloid Time: Because amyloid burden grows at a constant rate after having crossed a tipping point, scientists were able to predict when a person’s symptoms will begin, using only his or her age and one PET scan.
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