Deep Sleep Accelerates Synuclein Removal in Mice
Parkinson’s mice that got deeper slow-wave sleep cleared synuclein deposits, perhaps via better glymphatic function. Sleep deprivation worsened synuclein phosphorylation and aggregation.
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Parkinson’s mice that got deeper slow-wave sleep cleared synuclein deposits, perhaps via better glymphatic function. Sleep deprivation worsened synuclein phosphorylation and aggregation.
The EMA's decision was expected. Biogen announced it will appeal but also halved the drug's price. The company said it plans to complete a confirmatory trial by 2026.
Tissues from old people, both healthy and diseased, overexpress genes lacking C-G repeats. This stokes inflammation, possibly explaining why neurodegeneration rises with age.
Tau PET holds a slight edge over the plasma marker in people who already have mild cognitive impairment.
Funding will support risk factor research and public health messaging about lifestyle modifications.
AAV-based CRISPR snipped a piece of mutant APP and limited plaques in mice. Viruses that infiltrate only the CNS—and only neurons there—may facilitate localized gene editing in the brain.
People with subjective or mild cognitive impairment are less likely to get dementia if their CSF Aβ38 levels are high. Should γ-secretase modulators be revived?
A new study claims that diverse palettes of tau species exist in the hippocampi of people with AD. Four-repeat isoforms dominated in rapidly progressing disease.
The largest transcriptomic catalogue of live microglial cells to date, MiGA cinched causal connections between genetic variation, microglial gene expression, and disease.
Progranulin deficiency hyperactivates microglia, but calming these cells worsened synapse loss and neurodegeneration in mice.
Alzforum editors review the highlights of last year’s clinical and research developments.
The decision will curtail access until efficacy is shown. Many Alzheimer’s researchers call it a reasonable compromise, others question how it will work in practice.
Among 39 sets of identical twins, tau tangles accumulated in a strikingly similar pattern within each pair. A pair's discordance was due to Aβ and factors such as exercise.
MK-6884 measures allosteric changes to the M4 subtype of muscarinic receptors. Ligand binding tightened when people took donepezil, an acetylcholinesterase inhibitor.
An unbiased “interactome” generated from human neurons could shed light on what goes wrong in tauopathies, and help identify new therapeutic targets.
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