The Lactic Acid Shuttle—It May Change How We Image the Brain
In today’s Science, researchers at Cornell University provide compelling evidence that neurons preferentially use lactate as a source of energy...
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In today’s Science, researchers at Cornell University provide compelling evidence that neurons preferentially use lactate as a source of energy...
BioWorld Online yesterday reported that a phase 2 trial of the neurotrophic factor GDNF...
In yesterday’s Neuron, two independent laboratories report that the Histone Acetyl Transferase (HAT) activity of CREB-binding protein (CBP) is crucial for learning and memory...
Low-level, ongoing excitatory neurotransmission at synapses—so-called "minis"—keep the postsynaptic cell ready for rapid remodeling by capping local protein translation...
This past week, a flurry of studies advanced Parkinson’s research on several different fronts...
When a cell responds to stress or DNA damage, a variety of nuclear proteins undergo PolyADP-ribosylation. Beyond that, however, the requisite enzyme...
In today’s Sciencexpress, researchers at Harvard Medical School report that the mammalian protein SIRT1 promotes the survival of mammalian cells and suggest it may do so by...
Tangles, Neurodegeneration, Plaques—p25 Does it All American Society for Biochemistry and Molecular Biology: 2004 Annual Meeting
What, exactly, is the trigger for Alzheimer’s disease? Is there one such thing? At today’s annual meeting of the American Society for Biochemistry and Molecular Biology...
Researchers at the National Institute on Aging, Baltimore, report that Notch signaling is required for LTP in adults...
Aging is the strongest risk factor for Alzheimer’s disease, but exactly what it is about aging that underlies the pathology of AD, or cognitive decline in general, is...
People with Alzheimer's disease clearly have deficits in explicit memory—the type that can be deliberately accessed. But there is good evidence that some implicit memory processes...
High Ground for Protein Folding: Erene Mina Reports from Snowmass, Elevation 8,223 Protein Misfolding, Amyloid and Conformational Disease
Oxidative stress has been postulated as a major factor in the pathology of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD). However, evidence linking this type of stress to...
Mutations in the gene for the protein DJ-1 are known to cause early-onset Parkinson’s disease. Exactly what DJ-1 does is unknown, however, so how...
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