In Year Three, GAP Trial Network Is Starting to Hum
With three trials and initiatives to boost recruitment, GAP-Net is gaining some traction in the field.
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With three trials and initiatives to boost recruitment, GAP-Net is gaining some traction in the field.
From central IRBs, certified raters, to local transport: Changes large and small are needed to ramp up drug testing in Alzheimer’s.
Among 20 focus areas, 47 research recommendations cover the gamut from basic science to health disparities.
Award recognizes his contributions to basic and clinical research.
Analysis of 19 H1 MAPT subhaplotypes ties five to progressive supranuclear palsy.
Using rigorous tissue-processing techniques, researchers find thousands of newborn neurons in older human hippocampi, but a dearth in brains with AD pathology.
Experts said Phase 3 data did not prove the device could slow AD.
Women who started menstruation after the age of 16, and/or entered menopause before 47, had higher rates of dementia later in life.
A prospective progeria drug revs up cellular autophagy and clears tau in neurons derived from patients with frontotemporal dementia. In mouse models, the drug rescues abnormal behavior.
A majority of amyloid PET scans led physicians to change how they managed a patient’s disease. The effect on later outcomes is yet to be come.
Blocking the receptor clears toxic proteins and improves memory in old mice. The work proposes a new role in microglia for a well-known B-cell receptor.
A newly uncovered population of astrocytes in layer V of the cortex modulate synapses by secreting a protein linked to Norrie disease, a form of blindness. Are other disease-related astroglia lurking in the brain?
Boosting sTREM2 in the brain rallied microglia to clear Aβ plaques, restored synaptic plasticity, and even rescued memory deficits in mice.
Transcranial, alternating electrical current restored neuronal synchrony in older people, rejuvenating working memory. For an hour or two.
Senolytic drugs kill these cells, temper Aβ, and improve cognition in transgenic mice.
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