Scientists Eye Ocular Movements for Clues to Brain Pathology
Altered responses to visual stimuli could signify the extent of TDP-43 pathology in the brain, researchers predict.
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Altered responses to visual stimuli could signify the extent of TDP-43 pathology in the brain, researchers predict.
Exercising the brain and body in middle age may not limit progression of Alzheimer’s pathology.
Scientists match up PET scans of neurofibrillary tangles against Aβ imaging, CSF measures, and cognitive tests to see how biomarkers change relative to function.
Levels of neurofilament light in blood and spinal fluid of mice reflected brain pathology and changed with treatment.
Study of disease subtypes boosts case for NfL as predictor of rapidly progressing ALS.
Interim data from IDEAS study find that amyloid PET has a greater effect in real-world practice than in research settings. Nearly half of people diagnosed with AD did not have the disease.
Longitudinal neuroimaging of DIAN participants reveals that in most regions of the brain affected by AD pathology, Aβ accumulates first, then metabolism slows, then the brain shrinks.
What goes up can come down—rising tides of VILIP-1, neurogranin, and SNAP-25 ebb after onset of AD symptoms.
UCB-J hints at early synaptic loss in the hippocampus, but not the cortex. Researchers puzzle over the pattern.
Study links changes in the retina’s microvasculature to brain amyloid in cognitively normal adults.
The largest study so far to compare brain scans and CSF among African-Americans and Caucasians finds differences, but participant numbers remain small.
Among cognitively normal people with amyloid plaques, women have more tau tangles in the entorhinal cortex than do men. Does this indicate susceptibility, or resilience?
IBM researchers in Australia identify a combination of four proteins in plasma that predicts amyloid positivity in cerebrospinal fluid, and correlates with progression to AD.
In ADNI, blood marker exposes ongoing neurodegeneration across disease stages.
Serial amyloid and tau scans in cognitively healthy people indicate that the speed at which a person’s tau accumulates best predicts his or her future cognitive decline.