Multi-Paper Alert: More Data That Brain Amyloid Is Bad for You
The December 14 issue of Archives of Neurology features three papers and an editorial from scientists at Washington University in St Louis, Missouri...
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Worldwide Quality Control of CSF Biomarkers—How Does it Work?
Here, now, is a summary of the nuts and bolts of the QC program itself...
CSF Testing for AD: Single-center Bliss, Multicenter Woe?
When scientists compare different centers doing things their way, they see a large variation; even at a single site, variation occurs...
Worldwide Quality Control Set to Tame Biomarker Variation
This is a story about how differences among individual centers’ CSF Aβ and tau measurements are posing a serious problem...
St. Louis: Imaging Preclinical AD—Can You See it Coming in the Brain?
At the 7th Leonard Berg Symposium, brain imaging researchers of various stripes took stock of what brain imaging tells the field about the preclinical period of Alzheimer disease...
St. Louis: Biomarkers Pre-dementia—Like eFAD, Like LOAD?
As throughout this conference, talks toggled between what’s known in LOAD and eFAD, comparing all the while how well knowledge on these forms of AD matches up...
Stayin’ Alive—Huge Study Quickens Quest for Plasma AD Biomarker
Identifying people on the verge of dementia before they actually succumb has become somewhat of a Holy Grail for Alzheimer disease research...
Research Brief: ALS Leaves a Footprint in the Blood
Many researchers studying neurodegenerative disease focus their studies on the affected organs of the nervous system. But in doing so, they may be ignoring a more accessible place...
Uppsala: Brainstorming Biomarkers
Biomarkers were top of the agenda on the second day of Neurodegenerative Disorders—Immunotherapy and Biomarkers...
Vienna: New Tack to See Amyloid Oligomers in Body Fluids
The ICAD featured that the interest in small Aβ aggregates has branched out far beyond the initial debates about whether they even exist and which forms are important...
Uppsala: Immunotherapy and Biomarkers Take Center Stage
In addition to immunotherapy, a meeting in Uppsala, Sweden, focused on recent progress in the development of novel disease biomarkers...
Subjective Memory Complaint—Not So Subjective Anymore?
People who complain of troubling memory lapses but show no impairment in standard memory tests may take some solace from a recent European study...
Seeking a Reliable Yardstick for ALS Trials
To determine if a medicine works, scientists need reliable patient data, but the right numbers are not always easy to come by...
Research Brief: APL1β28—Surrogate for CNS Aβ42 Production?
Calculating the risk of impending AD based on levels of CSF Aβ42 has been tricky because the peptide forms insoluble aggregates that muddle estimates of its production rate in the CNS...
Meet Progranulin, The Biomarker—A Simpler Story?
Scientists wrestling the complexities of α-synuclein fluid biochemistry might be forgiven for looking with some envy to a different protein of the neurodegenerative disease spectrum...