Homing in on Early Alzheimer’s Biomarkers: Does Connectivity Hold the Key?
Researchers at AAIC proposed several different measures of brain connectivity that may predict progression to AD.
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Researchers at AAIC proposed several different measures of brain connectivity that may predict progression to AD.
Researchers at an international frontotemporal dementia congress reported progress in finding markers that track disease, but no luck thus far with diagnostic markers.
Preserved brain networks may explain the exceptional memory prowess of some older adults.
In Italian memory clinics, the PET scans resulted in diagnosis and medication changes for up to a third of patients.
Two international initiatives compile metadata from aging and AD studies into huge searchable catalogs in hopes of speeding research progress.
Before any other changes, the fatty coating on peripheral nerve fibers breaks apart, heralding their degeneration.
Where does TREM2-dependent microglial activity fit into the staging diagram of Alzheimer’s disease?
Researchers at SfN 2016 reported that oligomeric and exosomal forms in plasma predict AD as early as a decade prior to symptoms.
Cognitively normal people who harbor plaques in their brains are more likely to report feelings of isolation.
At CTAD, tau PET data from people in different stages of various neurodegenerative diseases highlighted both commonalities and peculiarities.
Diurnal variations disappear as less Aβ42 reaches cerebrospinal fluid. Findings may improve timing of daily amyloid treatments.
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
NIH funds a five-year project to validate biomarkers for clinical trials.
In the field’s march toward automated testing, scientists for the first time used biomarker cutoffs determined in one cohort to predict amyloid accumulation in a second. It worked.