Honolulu: Biomarker Profiles That Spell Trouble for ‘Normals’?
Scientists have drafted a new set of diagnostic research criteria redefining AD as a condition that develops decades prior to obvious symptoms...
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Revised Criteria for Preclinical AD, Exactly as Presented
Three workgroups of clinicians from the U.S. and Europe offered new guidelines for the diagnosis of AD...
Noisy Response Greets Revised Diagnostic Criteria for AD
Three groups presented results of their ongoing effort to incorporate scientific advances of the past quarter-century into a revision of the current diagnostic AD criteria...
DIAN Dispatch from Hawaii: Glimpse at Data, Push for Trials
Leaders of DIAN gathered to brief each other to present to some 30 pharmaceutical industry scientists the first cut of baseline data from this ongoing biomarker study...
New Findings Offer Hope for Down Syndrome
Conventional wisdom says that Down syndrome (DS) goes hand-in-hand with intellectual disability—but what if that was not true?...
Miami Beach: Biomarkers Weigh In at MCI Meeting
The Alzforum brings you a journalistic summary by reporter Pat McCaffrey enhanced by slide decks from the majority of presentations...
Classifying Motor Neuron Disease With CSF Markers
It is easy to confuse one motor neuron disease for another: amyotrophic lateral sclerosis, primary lateral sclerosis, and lower motor neuron disease can all mimic each other...
Geneva: Biomarker News Morsels Amid Immunotherapy Review
Advances in therapy saw little sprigs of news pop up in talks that otherwise took stock of the current status of immunotherapy as one of the major new approaches...
CSF Biomarkers Track With Atrophy, Cognition in Normal Aging
When judging the utility of cerebrospinal fluid biomarkers in Alzheimer disease, it may be less a question of if, but rather when and in whom...
Research Brief: Cerebral Blood Flow Ebbs In Aging E4 Carriers
Though ApoE4 genotype has for years topped the list of genetic risk factors for AD, scientists grapple with how this allele makes people more prone to AD...
Multi-Paper Alert: More Data That Brain Amyloid Is Bad for You
The December 14 issue of Archives of Neurology features three papers and an editorial from scientists at Washington University in St Louis, Missouri...
Worldwide Quality Control of CSF Biomarkers—How Does it Work?
Here, now, is a summary of the nuts and bolts of the QC program itself...
CSF Testing for AD: Single-center Bliss, Multicenter Woe?
When scientists compare different centers doing things their way, they see a large variation; even at a single site, variation occurs...
Worldwide Quality Control Set to Tame Biomarker Variation
This is a story about how differences among individual centers’ CSF Aβ and tau measurements are posing a serious problem...
St. Louis: Imaging Preclinical AD—Can You See it Coming in the Brain?
At the 7th Leonard Berg Symposium, brain imaging researchers of various stripes took stock of what brain imaging tells the field about the preclinical period of Alzheimer disease...