Amyloid Measures Predictably at Odds on Ends of Scales
The highs and lows of cerebrospinal fluid Aβ and PET amyloid imaging don't necessarily agree.
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The highs and lows of cerebrospinal fluid Aβ and PET amyloid imaging don't necessarily agree.
Deep brain stimulation helps many people with Parkinson’s, but how it does so remains a mystery. A new study suggests it normalizes brain rhythms.
Several different striatal markers may help researchers track early deterioration in Huntington's and Parkinson’s diseases.
Scientists find neurodegenerative proteins squirreled away in the skin cells of patients. Could this present an untapped source of biomarkers?
Probing this this Alzheimer’s risk factor, scientists find a novel variant, but no consensus yet on how this cell surface receptor increases risk for disease.
At AAIC, new data on three anti-Aβ antibodies reinforced a sense of hope that Aβ immunotherapy may yet work out. Challenges with each antibody notwithstanding, all four leading candidates, including crenezumab, are now in Phase 3.
Variability still plagues CSF biomarker measurements, but automated systems offer hope of a diagnostic assay.
Can proteins in the cerebrospinal fluid help tell movement disorders apart and predict who will develop dementia?
The synaptic protein abounds in the cerebrospinal fluid of AD patients and in those in the prodromal phase of the disease.
Scientists struggle to understand neurodegeneration in the SNAP syndrome.
Postmortem pathology confirms that some people who were diagnosed with AD during life had no appreciable amyloid in the brain, leaving researchers to puzzle over what caused their cognitive decline.
Neurogranin could be a promising early CSF biomarker of Alzheimer’s disease.
Moving toward a common standard for fluid-based Alzheimer’s diagnosis in routine clinical care, an intergovernmental metrology agency has certified a way of quantifying Aβ42.
The protein creeps up in the cerebrospinal fluid as the disease worsens.
Meet RBM45. This RNA-binding protein and relatively new player in the ALS field associates with stress-induced structures in the cytoplasm and nucleus.