HAI—Aβ: First in Alzheimer’s Cascade, or Just Another Player?
Scientists worldwide now perform amyloid imaging on scores of research participants to figure out how Aβ buildup relates to other markers of neurodegeneration...
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Metabolomics: Seeking Biomarkers for ALS, Parkinson’s, Huntington’s
Metabolomics has given researchers studying Alzheimer’s disease plenty to think about...
Are Soluble APP Fragments Markers for ALS?
Readers could be forgiven for doing a double-take at the title of a recent paper linking APP—best known for its role in Alzheimer’s disease—to ALS...
Optimizing CSF Aβ42 ELISA for Trials and Regulatory Approval
Testing a widely used cerebrospinal fluid Aβ42 immunoassay, scientists proposed modifications that they believe improve its precision and accuracy...
Keystone: Diagnosis and Model Treatments for Traumatic Brain Injury
Identifying injuries that might lead to chronic traumatic encephalopathy or other neurodegenerative pathologies, and then treating those injuries, are two major challenges...
Brain Connectivity Reveals Preclinical Alzheimer’s Disease
Brain connections weaken years before cognition in sporadic and familial Alzheimer’s.
Fluid Biomarkers Give Clues to Disease Progression in Parkinson’s
Preliminary data from Parkinson’s Progression Markers Initiative suggests that cerebrospinal fluid biomarkers distinguish the most rapidly progressing form of Parkinson’s.
Honolulu: Biomarker Profiles That Spell Trouble for ‘Normals’?
Scientists have drafted a new set of diagnostic research criteria redefining AD as a condition that develops decades prior to obvious symptoms...
Pieces Move Into Place to Stage Frontotemporal Trials
Speakers wanted to bring frontotemporal degeneration (FTD) to the attention of the pharmaceutical industry and trialists working in Alzheimer’s disease...
Oxidative Damage to the Olfactory Epithelium—Smells Like AD
Could biopsy of olfactory epithelium yield early warnings of Alzheimer's disease (AD)? This possibility was raised by George Perry and colleagues who report that oxidative damage to olfactory neurons could be a harbinger of impending AD...
Uppsala: Immunotherapy and Biomarkers Take Center Stage
In addition to immunotherapy, a meeting in Uppsala, Sweden, focused on recent progress in the development of novel disease biomarkers...
Risky Business—New Index Predicts Dementia in Older Adults
Unfortunately, there is no quick test for predicting Alzheimer disease (AD)—at least not yet...
ADNI: Mission Creep From Alzheimer Disease to Healthy Senior?
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) was originally conceived as an exploratory project to identify the best measures for tracking disease progression...
ApoE2 Carriers Have Less Brain Atrophy, AD Pathology in Spinal Fluid
The few people who have an ApoE2 allele enjoy reduced risk of late-onset Alzheimer’s disease...
More on Biomarkers That Signal Longevity
Humans who live longer display the same biomarkers found in laboratory animals who have restricted caloric intake. However, because these human subjects weren't actively restricting their caloric intake, there may be other ways to increase life span in humans...