In NFL Players, Brain Inflammation May Persist Years After Head Trauma
PET scans detect activated glial cells in current and recently retired professional football players up to 21 years after their last concussion.
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Serum NfL Detects Preclinical AD, Reflects Clinical Benefit
The neurodegeneration marker appears to track disease severity in AD and MS patients with great sensitivity.
Blood Neurofilament Light a Promising Biomarker for Alzheimer’s?
The largest study yet on neurofilament light chain suggests plasma levels rise with disease and correlate with other signs of neurodegeneration.
Blood Marker May Predict ALS Progression
Levels of a neuronal protein in blood correlated with rate of decline in two U.K. cohorts.
In DIAN, Serial and Cross-Sectional Biomarker Trajectories Diverge
Serial data establishes different trajectories for CSF t-tau and p-tau.
New PET Tracer Selectively Lights Up Activated Microglia in Brain
The ligand binds the microglia-specific CSF1 receptor in animal and postmortem studies; human trials are forthcoming.
Tau, More than Aβ, Affects Sleep Early in Alzheimer’s
During deep sleep, people with AD pathology, particularly tau tangles, have less low-frequency slow-wave brain activity, which is important for memory consolidation.
Amyloid-PET Results Lead Some to Ponder Assisted Death in Future
In a research study, one-fifth of healthy people who learned they were at high risk for AD said they might consider physician-assisted death as a future option.
In Colombian Alzheimer’s Kindred, Blood NfL Climbs 22 Years Before Symptoms
The plasma biomarker neurofilament light was able to distinguish individual mutation carriers from noncarriers three years prior to onset.
Klotho VS Variant Preserves Memory by Preventing Tangles
Carriers accumulate fewer tangles than noncarriers for a given amount of amyloid, explaining how the gene variant may lower a person’s Alzheimer’s risk.
Touchdown for NfL: Blood Test Tells Parkinson's from Related Disorders
A simple blood draw may help distinguish garden-variety PD from other, less common parkinsonian disorders early in disease.
Mysterious RNA Circles Crop up in Alzheimer’s Brain
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
Simulating Tangle Spread Along Axons, Scientists Predict Tau PET Patterns
The modeling approach reinforces the idea that tau pathology propagates through the brain’s physical architecture, including neuronal networks.
Plasma P-Tau181 Predicts, Monitors Alzheimer’s Progression
The blood-based marker may be far more scalable and cost-effective for tracking the disease than PET imaging and CSF biomarkers.
How Does COVID-19 Affect the Brain?
Some people with severe COVID-19 have neurovascular injury and elevated markers of neural damage in their blood and CSF. What’s going on in their brains?
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