A behavioral variant of Alzheimer’s disease is not accompanied by shrinking of the frontal cortex. Rather, these patients have similar patterns of atrophy as those with typical AD.
Grid cells in the entorhinal cortex help with spatial navigation, and the cells’ function falters in young people at risk for AD.
Alois was right: Among cognitively normal middle-aged people followed for more than a decade, memory worsened only in those in whom markers for both amyloid and tau were abnormal.
A comparison of blood proteins between health and dementia uncovers faulty differentiation signaling, which may have harmful effects on neurogenesis.
Researchers at AAIC discussed technical limitations of current tracers and ways to improve the signal. A new ligand debuted that may be more specific for tangles.
In a validation study, three common software packages produced excessive false positives, but initial stories about previous suspect data might have been overblown.
Unlikely a disease marker, poly glycine-proline might track therapeutic efficacy in clinical trials.
Longitudinal ADNI data revealed that people with elevated Aβ declined toward AD, while those with normal levels maintained their cognitive abilities.
New diagnostic guidelines on dementia with Lewy bodies fold in science about sleep and the heart, two aspects that distinguish this disorder from Alzheimer’s and Parkinson’s.
In a pilot study, a curcumin-based probe allowed researchers to detect retinal amyloid deposits in AD patients, but it remains to be seen if this can serve as an early biomarker.
Participants in the A4 prevention trial wanted to know the extent of their amyloid burdens and how that affected their risk for AD. Researchers need to carefully communicate the limitations of amyloid PET.
Injecting 13C-labeled leucine intravenously, researchers tracked tau turnover in the human brain and cerebrospinal fluid for the first time.
ApoE4 raises CSF tau more in women than in men, suggesting sex may influence the risk of neurodegeneration, especially in amyloid-positive E4 carriers.
PET scans detect activated glial cells in current and recently retired professional football players up to 21 years after their last concussion.
The neurodegeneration marker appears to track disease severity in AD and MS patients with great sensitivity.